Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-

Base Information

• Chemical Name: Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-
• CAS No.: 890658-79-4
• Molecular Formula: C10H11FO5S
• Molecular Weight: 262.259
• Mol file: 890658-79-4.mol

Synonyms:

Chemical Property of Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-

There total 7 articles about Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C10H13FO4S (928312-15-6) → C10H11FO5S (890658-79-4)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In phosphate buffer; acetonitrile; at 35 ℃; for 24h;

DOI:10.1016/j.tetlet.2006.12.011

Reference yield:

sodium 4-fluorobenzenesulfinate (824-80-6) → C10H11FO5S (890658-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-hydroxyphthalimide; diisopropyl-carbodiimide; dmap / dichloromethane / 20 °C / Sealed tube

1.2: 12 h / 20 °C / Inert atmosphere; Irradiation

2.1: potassium hydroxide / methanol; water / 2 h / 220 °C

With dmap; N-hydroxyphthalimide; potassium hydroxide; diisopropyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1016/j.chempr.2020.02.003

Reference yield:

(2S,5R)-2-(tert-butyl)-5-(((4-fluorophenyl)sulfonyl)methyl)-5-methyl-1,3-dioxolan-4-one → C10H11FO5S (890658-79-4)

Guidance literature:

With potassium hydroxide; In methanol; water; at 220 ℃; for 2h;

DOI:10.1016/j.chempr.2020.02.003

upstream raw materials:

C₁₀H₁₃FO₄S

C₁₇H₁₉FO₂S

C₁₇H₁₉FO₄S

4-Fluorothiophenol

Downstream raw materials:

(R)-bicalutamide

Refernces

• 1、 -. "ANDROGEN RECEPTOR ANTAGONISTS". . . Retrieved 2016/04/26.