Propanoic acid, 3-hydroxy-2-methyl-, ethyl ester

Base Information

• Chemical Name: Propanoic acid, 3-hydroxy-2-methyl-, ethyl ester
• CAS No.: 89534-52-1
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Hs Code.: 2918199090
• Mol file: 89534-52-1.mol

Synonyms:Hydracrylic acid, 2-methyl-, ethyl ester;Ethyl 3-hydroxyisobutanoate;Ethyl 2-(hydroxymethyl)propionate;

Chemical Property of Propanoic acid, 3-hydroxy-2-methyl-, ethyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 0.17790

Purity/Quality:

98% ^*data from raw suppliers

Ethyl3-hydroxy-2-methylpropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-hydroxy-2-methyl-, ethyl ester

There total 11 articles about Propanoic acid, 3-hydroxy-2-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 3-hydroxy-2-methyl-propionic acid ethyl ester (89534-52-1)

Guidance literature:

Ethyl 2-bromopropionate; With indium; In tetrahydrofuran; for 0.333333h; Sonication;

formaldehyd; In tetrahydrofuran; for 4h; Sonication;

DOI:10.1055/s-0030-1258581

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-formylpropionate (27772-62-9) + Ethyl propionate (105-37-3,20741-13-3) + 3-hydroxy-2-methyl-propionic acid ethyl ester (89534-52-1) + 4-ethoxycarbonyl-4-methyl-δ-valerolactone

Guidance literature:

With hydrogen; {HRu(CO)4}-; In N,N-dimethyl-formamide; at 100 ℃; for 16.5h; under 228000 Torr; Further byproducts given;

DOI:10.1016/0022-328X(88)83126-7

Reference yield:

carbon monoxide (201230-82-2) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-formylpropionate (27772-62-9) + Ethyl propionate (105-37-3,20741-13-3) + 3-hydroxy-2-methyl-propionic acid ethyl ester (89534-52-1) + 4-ethoxycarbonyl-4-methyl-δ-valerolactone

Guidance literature:

With hydrogen; {HRu(CO)4}-; In N,N-dimethyl-formamide; at 100 ℃; for 16.5h; under 228000 Torr; Further byproducts given;

DOI:10.1016/0022-328X(88)83126-7

upstream raw materials:

ethyl 2-formylpropionate

formaldehyd

1-ethoxy-1-propyne

carbon monoxide

Downstream raw materials:

ethyl ester of β-bromoisobutyric acid

Ethyl β-chloro-α-methylpropionate

3-hydroxyisobutyric acid

2-chloro-4-fluoro-5-nitrobenzoic acid(1-methyl-1-ethoxycarbonyl)ethyl ester

Refernces

• 1、 Burda, Edyta,Krausser, Marina,Fischer, Gabriele,Hummel, Werner,Mueller-Uri, Frieder,Kreis, Wolfgang,Groeger, Harald. "Recombinant Δ4,5-steroid 5 β-reductases as biocatalysts for the reduction of activated C=C-double bonds in monocyclic and acyclic molecules". experimental part. p. 2787 - 2790. Retrieved 2010/03/05.
• 2、 Hayashi, Teruyuki,Gu, Zheng Hui,Sakakura, Toshiyasu,Tanaka, Masato. "High catalytic activity of - for hydroformylation of olefins". . p. 373 - 378. Retrieved 2007/10/02.