(2r)-3-Hydroxy-2-Methylpropanoic Acid

Base Information

• Chemical Name: (2r)-3-Hydroxy-2-Methylpropanoic Acid
• CAS No.: 1910-47-0
• Molecular Formula: C4H8 O3
• Molecular Weight: 104.106
• Hs Code.: 2918199090
• UNII: Y76AVU7W7K
• DSSTox Substance ID: DTXSID00940694
• Nikkaji Number: J61.902G
• Wikidata: Q27461109
• Metabolomics Workbench ID: 1499
• Mol file: 1910-47-0.mol

Synonyms:1910-47-0;(R)-3-hydroxy-2-methylpropanoic acid;(R)-2-Hydroxymethylpropanoic acid;(R)-3-Hydroxyisobutyric acid;(2r)-3-Hydroxy-2-Methylpropanoic Acid;Propanoic acid, 3-hydroxy-2-methyl-, (2R)-;D-(-)-3-Hydroxyisobutyric acid;3R-hydroxy-isobutyric acid;Y76AVU7W7K;3-Hydroxyisobutyric acid, (R)-;2R-methyl-3-hydroxy-propanoic acid;Hydracrylic acid, 2-methyl-, (R)-;(R)-3-Hydroxy-2-methylpropionate;3-hydroxy-2-methylpropionate;HIU;D-b-Hydroxyisobutyrate;R-b-Hydroxyisobutyrate;d-3-hydroxyisobutyrate;R-beta-Hydroxyisobutyrate;D-b-Hydroxyisobutyric acid;R-b-Hydroxyisobutyric acid;UNII-Y76AVU7W7K;2-methyl-(R)-Hydracrylate;delta-beta-Hydroxyisobutyrate;D-beta-Hydroxyisobutyric acid;R-beta-Hydroxyisobutyric acid;D-(-)-3-Hydroxyisobutyrate;SCHEMBL791884;2-methyl-(R)-Hydracrylic acid;delta-(-)-3-Hydroxyisobutyrate;delta-beta-Hydroxyisobutyric acid;(r)-beta-hydroxy-isobutyric acid;DTXSID00940694;DBXBTMSZEOQQDU-GSVOUGTGSA-N;delta-(-)-3-Hydroxyisobutyric acid;(R)-3-hydroxy-2-methylpropanoicacid;FD6004;LMFA01050382;MFCD06656409;AKOS016842976;(R)-3-Hydroxy-2-methylpropionic acid;AC-9519;D-.BETA.-HYDROXYISOBUTYRIC ACID;(2R)-2-methyl-3-hydroxypropionic acid;(R)-3-Hydroxy-2-methyl-propionic acid;AS-49261;HY-113108;A4216;CS-0059595;Q27461109

Chemical Property of (2r)-3-Hydroxy-2-Methylpropanoic Acid

Chemical Property:

• Vapor Pressure: 0.00292mmHg at 25°C
• Boiling Point: 252.9°Cat760mmHg
• Flash Point: 121°C
• PSA: 57.53000
• Density: 1.195g/cm³
• LogP: -0.30060
• Storage Temp.: 2-8°C
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.047344113
• Heavy Atom Count: 7
• Complexity: 69.3

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-Hydroxy-2-methylpropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)C(=O)O
• Isomeric SMILES: C[C@H](CO)C(=O)O

Technology Process of (2r)-3-Hydroxy-2-Methylpropanoic Acid

There total 16 articles about (2r)-3-Hydroxy-2-Methylpropanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C8H10F3NO5 → 3-hydroxyisobutyric acid (1910-47-0,2068-83-9,26543-05-5,44520-17-4)

Guidance literature:

With methanol; potassium carbonate; at 60 ℃;

DOI:10.1021/ol403393w

Reference yield: 100.0%

1S-cyclohexyl-3R-1,4-dihydroxybutan-2-one → (R)-3-hydroxy-2-methyl propionic acid (1910-47-0)

Guidance literature:

With sodium periodate; In methanol; water; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(01)81956-0

Reference yield: 91.0%

2-methyl-1.3-propanediol (2163-42-0) → (R)-3-hydroxy-2-methyl propionic acid (1910-47-0)

Guidance literature:

With Acetobacter aceti MIM 2000/28; air; In water; at 28 ℃; for 0.166667h; regioselective reaction; Flow reactor; Enzymatic reaction;

DOI:10.1002/open.201700082

upstream raw materials:

3-benzyloxy-2-methylpropionic acid

Ethyl 2-bromopropionate

kaempferol 3-O-β-D-(6-O-3-hydroxyisobutyryl)glucopyranosyl-(1->4)-α-L-rhamnopyaranosyl-7-O-β-D-glucopyranoside

3-hydroxy-2-methyl-propionic acid ethyl ester

Downstream raw materials:

methyl (R)-3-hydroxy-2-methylpropionate

2-methyl-3-chloropropionyl chloride

2,2,5-trimethyl-1,3-dioxane-5-carboxylic acid

poly(methacrylic acid)

Refernces

• 1、 Kawagishi, Hirokazu,Murakami, Hiroaki,Sakai, Shingo,Inoue, Shintaro. "Carnitine-esters from the mushroom Suillus laricinus". . p. 2676 - 2680. Retrieved 2006.
• 2、 Pickl, Mathias,Marín-Valls, Roser,Joglar, Jesús,Bujons, Jordi,Clapés, Pere. "Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from l-α-Amino Acids". . p. 2866 - 2876. Retrieved 2021/04/14.
• 3、 Zhou, Lihong,Lu, Wenjun. "Palladium-catalyzed β-acyloxylation of simple amide via sp3 C-H activation". supporting information. p. 508 - 511. Retrieved 2014/04/03.