Tetrahydro-4-oxo-3-furoic acid ethyl ester

Base Information

• Chemical Name: Tetrahydro-4-oxo-3-furoic acid ethyl ester
• CAS No.: 89898-51-1
• Molecular Formula: C7H10O4
• Molecular Weight: 158.154
• Hs Code.: 2932190090
• Mol file: 89898-51-1.mol

Synonyms:Ethyl 4-oxo-tetrahydrofuran-3-carboxylate;

Chemical Property of Tetrahydro-4-oxo-3-furoic acid ethyl ester

Chemical Property:

• Boiling Point: 237℃
• PKA: 10.75±0.20(Predicted)
• Flash Point: 99℃
• PSA: 52.60000
• Density: 1.213
• LogP: -0.23500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl4-oxotetrahydrofuran-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-4-oxo-3-furoic acid ethyl ester

There total 1 articles about Tetrahydro-4-oxo-3-furoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

ethyl 2-hydroxyacetate (623-50-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl tetrahydrofuran-3-one 4-carboxylate (89898-51-1)

Guidance literature:

ethyl 2-hydroxyacetate; With triethylamine; In dimethyl sulfoxide; at 30 ℃; for 0.1h;

ethyl acrylate; In dimethyl sulfoxide; for 17h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 82.3%

ethyl tetrahydrofuran-3-one 4-carboxylate (89898-51-1) → tetrahydrofuran-3-one (22929-52-8)

Guidance literature:

With sulfuric acid; at 80 ℃; for 5h; Reagent/catalyst;

Reference yield: 54.0%

ethyl tetrahydrofuran-3-one 4-carboxylate (89898-51-1) + urea (57-13-6) → 5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione (848398-40-3)

Guidance literature:

ethyl tetrahydrofuran-3-one 4-carboxylate; urea; With hydrogenchloride; In methanol; water; at 0 ℃; for 2.25h; Reflux;

With sodium hydroxide; In water; for 1h; Reflux;

upstream raw materials:

ethyl 2-hydroxyacetate

ethyl acrylate

Downstream raw materials:

5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione

2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine

N-benzyl-2-(2-methyl-2H-indol-1(7aH)-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine

C₁₃H₁₂ClN₃O

Refernces

• 1、 -. "FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX". Page/Page column 181. . Retrieved 2014/02/15.
• 2、 -. "HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA". Page 129; 130. . Retrieved 2010/02/06.