848398-40-3 Usage
Description
1H,2H,3H,4H,5H,7H-Furo[3,4-d]pyrimidine-2,4-dione, also known as uracil-6,8-dione, is a heterocyclic compound characterized by a fused pyrimidine ring system. It is a derivative of uracil, a fundamental component of RNA. 1H,2H,3H,4H,5H,7H-FURO[3,4-D]PYRIMIDINE-2,4-DIONE holds promise in medicinal chemistry and drug development, particularly for the design of antiviral and anticancer agents. Its unique molecular structure and properties make it a valuable subject for further research and exploration in pharmacology.
Uses
Used in Pharmaceutical Industry:
1H,2H,3H,4H,5H,7H-Furo[3,4-d]pyrimidine-2,4-dione is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential antiviral and anticancer properties. Its unique structure allows for the development of new drugs that can target specific viral and cancer-related pathways, offering novel treatment options for patients.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1H,2H,3H,4H,5H,7H-Furo[3,4-d]pyrimidine-2,4-dione serves as a valuable compound for studying the structure-activity relationships of potential drug candidates. Researchers can use this compound to understand how modifications to its structure can influence its biological activity, leading to the discovery of more effective and targeted therapeutic agents.
Used in Drug Development:
1H,2H,3H,4H,5H,7H-Furo[3,4-d]pyrimidine-2,4-dione is utilized in drug development for its potential to be incorporated into new antiviral and anticancer drugs. Its unique molecular features make it an attractive candidate for the creation of innovative medications that can address unmet medical needs and improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 848398-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,8,3,9 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 848398-40:
(8*8)+(7*4)+(6*8)+(5*3)+(4*9)+(3*8)+(2*4)+(1*0)=223
223 % 10 = 3
So 848398-40-3 is a valid CAS Registry Number.
848398-40-3Relevant articles and documents
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation
Brogi, Simone,Brindisi, Margherita,Butini, Stefania,Kshirsagar, Giridhar U.,Maramai, Samuele,Chemi, Giulia,Gemma, Sandra,Campiani, Giuseppe,Novellino, Ettore,Fiorenzani, Paolo,Pinassi, Jessica,Aloisi, Anna Maria,Gynther, Mikko,Venskutonyte, Raminta,Han, Liwei,Frydenvang, Karla,Kastrup, Jette Sandholm,Pickering, Darryl S.
supporting information, p. 2124 - 2130 (2018/03/21)
Starting from 1-4 and 7 structural templates, analogues based on bioisosteric replacements (5a-c vs 1, 2 and 6 vs 7) were synthesized for completing the SAR analysis. Interesting binding properties at GluA2, GluK1, and GluK3 receptors were discovered. The requirements for GluK3 interaction were elucidated by determining the X-ray structures of the GluK3-LBD with 2 and 5c and by computational studies. Antinociceptive potential was demonstrated for GluK1 partial agonist 3 and antagonist 7 (2 mg/kg ip).
OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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Page/Page column 80-81, (2011/01/05)
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
