89898-51-1

Basic information

• Product Name: Tetrahydro-4-oxo-3-furoic acid ethyl ester
• Synonyms: Tetrahydro-4-oxo-3-furoic acid ethyl ester;4-Oxo-tetrahydro-furan-3-carboxylic acid ethyl ester;Ethyl 4-Oxotetrahydrofuran-3-Carboxylate(WX618533)
• CAS NO: 89898-51-1
• Molecular Formula: C₇H₁₀O₄
• Molecular Weight: 158.1519
• Mol File: 89898-51-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 237℃
• Flash Point: 99℃
• Appearance: /
• Density: 1.213
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.75±0.20(Predicted)
• CAS DataBase Reference: Tetrahydro-4-oxo-3-furoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-4-oxo-3-furoic acid ethyl ester(89898-51-1)
• EPA Substance Registry System: Tetrahydro-4-oxo-3-furoic acid ethyl ester(89898-51-1)

Safety Data

• Hazardous Substances Data: 89898-51-1(Hazardous Substances Data)

Usage

General Description

Tetrahydro-4-oxo-3-furoic acid ethyl ester is a chemical compound that is a derivative of furoic acid. It is an ethyl ester, which is a type of organic compound commonly used in perfumery and flavoring. Tetrahydro-4-oxo-3-furoic acid ethyl ester is known for its sweet, fruity odor and is often used as a flavoring agent in food products. It is also used in the production of pharmaceuticals and as a precursor in the synthesis of other organic compounds. Tetrahydro-4-oxo-3-furoic acid ethyl ester is a versatile chemical with a wide range of industrial applications.

Upstream product

• 623-50-7 ethyl 2-hydroxyacetate 
• 140-88-5 ethyl acrylate 

Downstream Products

• 22929-52-8 tetrahydrofuran-3-one 
• 1542711-45-4 C₁₃H₁₂ClN₃O 
• 1542710-75-7 N-benzyl-2-(2-methyl-2H-indol-1(7aH)-yl)-5,7-dihydrofuro[3,4-d]pyrimidin-4-amine 
• 848398-41-4 2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine 
• 848398-40-3 5,7-dihydrofuro[3,4-d]pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Synthesis method of tetrahydrofuran-3-ketone

The invention discloses a synthesis method of tetrahydrofuran-3-ketone. The method comprises the following steps of: under an alkaline condition, mixing glycolate (I) and acrylate (II) in a solvent, and carrying out condensation cyclization reaction to obtain 4-formic ester-tetrahydrofuran-3-ketone (III); then, under an acidic condition, performing reflux decarboxylation reaction on the 4-formic ester-tetrahydrofuran-3-ketone (III) so as to obtain thetetrahydrofuran-3-ketone (IV) . According to the synthesis method of the tetrahydrofuran-3-ketone, the yield is greater than 82%; and the method has the advantages of mild and easily-controlled conditions, mild reaction, simple and safe operation and environmental friendliness.

OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).