3-(2-Piperidyl)-1-propanol Hydrochloride

Base Information

• Chemical Name: 3-(2-Piperidyl)-1-propanol Hydrochloride
• CAS No.: 90226-88-3
• Molecular Formula: C8H17NO.ClH
• Molecular Weight: 179.69
• Hs Code.: 2933399090
• Mol file: 90226-88-3.mol

Synonyms:90226-88-3;3-(2-Piperidyl)-1-propanol Hydrochloride;3-(Piperidin-2-yl)propan-1-ol hydrochloride;3-piperidin-2-ylpropan-1-ol;hydrochloride;3-(PIPERIDIN-2-YL)PROPAN-1-OL HCL;3-Piperidin-2-yl-propan-1-ol hydrochloride;MFCD22573686;2-Piperidinepropanol, hydrochloride;2-Piperidinepropanol hydrochloride;3-(2-Piperidyl)-1-propanolHydrochloride;SCHEMBL10759624;KAYHGTJWECNNBL-UHFFFAOYSA-N;AKOS022186968;SB41348;AM101541;AS-37507;SY023124;DB-303647

Chemical Property of 3-(2-Piperidyl)-1-propanol Hydrochloride

Chemical Property:

• PSA: 32.26000
• LogP: 2.03180
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.1076919
• Heavy Atom Count: 11
• Complexity: 85.3

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Piperidyl)-1-propanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CCCO.Cl

Technology Process of 3-(2-Piperidyl)-1-propanol Hydrochloride

There total 1 articles about 3-(2-Piperidyl)-1-propanol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

3-(pyridin-2-yl)-propanol (2859-68-9) → 3-(piperidin-2-yl)propan-1-ol hydrochloride (90226-88-3)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In ethanol; at 20 ℃; for 16h; under 2327.23 Torr;

Reference yield: 66.7%

benzyl bromide (100-39-0) + 3-(piperidin-2-yl)propan-1-ol hydrochloride (90226-88-3) → 3-(1-benzylpiperidin-2-yl)propan-1-ol

Guidance literature:

With potassium carbonate; In ethanol; for 2h; Cooling with ice; Reflux;

Reference yield:

3-(piperidin-2-yl)propan-1-ol hydrochloride (90226-88-3) → [3-(1-benzylpiperidin-2-yl)propyl]indan-2-ylphenylamine (1393836-84-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / ethanol / 2 h / Reflux

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

2.2: -78 - 20 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice

4.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 110 °C / Inert atmosphere

With oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In ethanol; dichloromethane; toluene;

upstream raw materials:

3-(pyridin-2-yl)-propanol

Downstream raw materials:

3-(1-benzylpiperidin-2-yl)propionaldehyde

[3-(1-benzylpiperidin-2-yl)propyl]indan-2-ylamine

[3-(1-benzylpiperidin-2-yl)propyl]indan-2-ylphenylamine

indan-2-ylphenyl-(3-piperidin-2-ylpropyl)amine

Refernces

• 1、 -. "Aminoindane Compounds and Use Thereof in Treating Pain". Page/Page column 65-67. . Retrieved 2012/09/05.