Safinamide mesylate

Base Information Edit

Chemical Name:Safinamide mesylate
CAS No.:202825-46-5
Molecular Formula:C18H23FN2O5S
Molecular Weight:398.449
Hs Code.:2924299090
European Community (EC) Number:606-485-0
UNII:YS90V3DTX0
DSSTox Substance ID:DTXSID80942414
Wikidata:Q27294690
NCI Thesaurus Code:C81331
RXCUI:1922449
ChEMBL ID:CHEMBL48582
Mol file:202825-46-5.mol

Synonyms:(S)-2-((4-(3-fluorobenzoxy)benzyl)amino)propanamide;2-(4-(3-fluorobenzyloxy)benzylamino)propionamide;fbap methanesulfonate;FCE 26743;FCE 28073;FCE-26743;FCE-28073;NW-1015;PNU 151774E;PNU-151774E;safinamide;safinamide methanesulfonate;Xadago

Suppliers and Price of Safinamide mesylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SafinamideMesylate
25mg
$ 180.00

Sigma-Aldrich
Safinamide mesylate salt ≥98% (HPLC)
5mg
$ 111.00

Sigma-Aldrich
Safinamide mesylate salt ≥98% (HPLC)
25mg
$ 432.00

Matrix Scientific
(S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)-amino)propanamide methanesulfonate 95+%
250mg
$ 5670.00

DC Chemicals
Safinamidemesylate >98%
100 mg
$ 400.00

ChemScene
Safinamide(mesylate) 99.18%
50mg
$ 288.00

ChemScene
Safinamide(mesylate) 99.18%
10mg
$ 96.00

Cayman Chemical
Safinamide (mesylate) ≥98%
10mg
$ 93.00

Cayman Chemical
Safinamide (mesylate) ≥98%
5mg
$ 49.00

Cayman Chemical
Safinamide (mesylate) ≥98%
25mg
$ 221.00

Total 104 raw suppliers

Chemical Property of Safinamide mesylate Edit

Chemical Property:

Vapor Pressure:2.98E-09mmHg at 25°C
Melting Point:210° (dec)
Boiling Point:476.7°Cat760mmHg
Flash Point:242.1°C
PSA：127.10000
Density:g/cm³
LogP:4.04410
Storage Temp.:2-8°C
Solubility.:H2O: ≥15mg/mL
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:398.13117117
Heavy Atom Count:27
Complexity:438

Purity/Quality:

98%min ^*data from raw suppliers

SafinamideMesylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O
Isomeric SMILES:C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O
Recent ClinicalTrials:Effect of Safinamide on Parkinson's Disease Related Chronic Pain
Recent EU Clinical Trials:A randomized, double-blind, placebo controlled, multicentre study to evaluate the effect of safinamide on freezing of gait (FOG) in mid- to late-stage fluctuating PD patients
Description Safinamide methanesulfonate was approved in February 2015 by the EMA for the treatment of mid- to late-stage fluctuating Parkinson’s disease. This approval included use of the drug as an add-on therapy for use with levodopa, either alone or in combination with other existing therapies for Parkinson’s disease.51 Safinamide methanesulfonate, an oral α-aminoamide originally discovered by Farmitalia Carlo Erba and later developed by Newron/Zambon, functions as a highly selective and reversible inhibitor of MAO-B, leading to increased levels of dopamine and subsequent improvement in the motor symptoms of Parkinson’s disease, side effects that often result from use of other traditional treatments relying on dopamine replacement therapy.
Uses Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).

Technology Process of Safinamide mesylate

There total 21 articles about Safinamide mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.33%