Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R)-

Base Information

• Chemical Name: Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R)-
• CAS No.: 174756-44-6
• Molecular Formula: C17H19 F N2 O2
• Molecular Weight: 302.348
• Mol file: 174756-44-6.mol

Synonyms:Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (R)-; (R)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide;FCE 28073

Chemical Property of Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R)-

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R)-

There total 6 articles about Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(3-fluoro-benzyloxy)-benzaldehyde (66742-57-2) + D-alaninamide hydrochloride (71810-97-4) → FCE 28073 (174756-44-6)

Guidance literature:

D-alaninamide hydrochloride; With triethylamine; In methanol; at 30 ℃; for 0.166667h;

4-(3-fluoro-benzyloxy)-benzaldehyde; In methanol; at 30 ℃; for 3.5h;

With sodium hydroxide; sodium tetrahydroborate; In methanol; water; at 5 ℃; for 2h; Product distribution / selectivity;

Reference yield:

4-(3-fluoro-benzyloxy)-benzaldehyde (66742-57-2) + 2-aminopropanamide hydrochloride (80222-96-4) → safinamide (133865-89-1) + FCE 28073 (174756-44-6)

Guidance literature:

4-(3-fluoro-benzyloxy)-benzaldehyde; 2-aminopropanamide hydrochloride; With triethylamine; In methanol; at 25 ℃; for 10.1667h;

With sodium hydroxide; sodium tetrahydroborate; In methanol; water; at 5 - 10 ℃; for 1h; Product distribution / selectivity;

Reference yield:

4-(3-fluoro-benzyloxy)-benzaldehyde (66742-57-2) + (S)-alaninamide hydrochloride (33208-99-0) → safinamide (133865-89-1) + FCE 28073 (174756-44-6)

Guidance literature:

(S)-alaninamide hydrochloride; With sodium methylate; In methanol; ethanol; at 17 - 23 ℃; for 1.25h;

4-(3-fluoro-benzyloxy)-benzaldehyde; In methanol; at 20 ℃; for 20.5h;

With sodium tetrahydroborate; In methanol; at 3 - 10 ℃; for 2h; Product distribution / selectivity;

upstream raw materials:

3-fluoro-benzenemethanol

N-(9-fluorenylmethoxycarbonyl)-D-alanine

4-(triisopropylsilyloxy)benzaldehyde

4-(3-fluoro-benzyloxy)-benzaldehyde

Downstream raw materials:

(R)-2-[4-(3-fluorobenzyloxy)benzylamino]propanamide methanesulfonate

Refernces

• 1、 -. "PROCESS FOR THE PRODUCTION OF 2-[4-(3- OR 2-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDES WITH HIGH PURITY DEGREE". Page/Page column 66. . Retrieved 2009/07/17.