1,5-naphthyridine N-(1)-oxide

Base Information

• Chemical Name: 1,5-naphthyridine N-(1)-oxide
• CAS No.: 27305-48-2
• Molecular Formula: C8H6 N2 O
• Molecular Weight: 146.148
• Mol file: 27305-48-2.mol

Synonyms:1,5-NaphthyridineN-oxide; NSC 364754

Chemical Property of 1,5-naphthyridine N-(1)-oxide

Chemical Property:

• Vapor Pressure: 0.000671mmHg at 25°C
• Melting Point: 150-151℃ (hexane )
• Boiling Point: 318.5°Cat760mmHg
• PKA: 2.09±0.40(Predicted)
• Flash Point: 146.4°C
• PSA: 38.35000
• Density: 1.24g/cm³
• LogP: 1.66330

Purity/Quality:

98% ^*data from raw suppliers

1,5-NaphthyridineN-(1)-oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,5-naphthyridine N-(1)-oxide

There total 4 articles about 1,5-naphthyridine N-(1)-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,5-naphthyridine (254-79-5) → 1,5-naphthyridine N-(1)-oxide (27305-48-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; at 20 ℃;

Reference yield:

pyridin-3-ylamine (462-08-8) → 1,5-naphthyridine N-(1)-oxide (27305-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₃aso4; concentrated H₂SO₄ / 170 °C

2: peroxyacetic acid; acetic acid

With peracetic acid; sulfuric acid; orthoarsenic acid; acetic acid;

DOI:10.1039/jr9540001879

Reference yield:

1,5-naphthyridine (254-79-5) + peracetic acid (79-21-0) + acetic acid (64-19-7,77671-22-8) → 1,5-naphthyridine N-(1)-oxide (27305-48-2) + 1,5-naphthyridine 1,5-dioxide (27305-49-3)

Guidance literature:

DOI:10.1039/jr9540001879

upstream raw materials:

1,5-naphthyridine

peracetic acid

acetic acid

pyridin-3-ylamine

Downstream raw materials:

2-chloro-1,5-naphthyridine

7-bromo-2-chloro-1,5-naphthyridine

7-bromo-1,2-dihydro-1,5-naphthyridin-2-one

2-bromo-1,5-naphthyridine

Refernces

• 1、 -. "INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS". Page/Page column 40; 44. . Retrieved 2022/02/05.
• 2、 -. "ALK5 INHIBITORS". Paragraph 0479; 0642; 0643. . Retrieved 2020/07/07.