2-Chloro-1,5-naphthyridine

Base Information

• Chemical Name: 2-Chloro-1,5-naphthyridine
• CAS No.: 7689-62-5
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• European Community (EC) Number: 866-119-2
• DSSTox Substance ID: DTXSID60569183
• Wikidata: Q72455602
• Mol file: 7689-62-5.mol

Synonyms:2-CHLORO-1,5-NAPHTHYRIDINE;7689-62-5;1,5-Naphthyridine, 2-chloro-;MFCD13189452;SCHEMBL252490;DTXSID60569183;JUYRQGHDOBBUEA-UHFFFAOYSA-N;2-Chloro-1 pound not5-naphthyridine;AKOS016001474;DS-2205;PB18055;SY027090;AM20061497;CS-0043840;EN300-248737;F2147-5476

Chemical Property of 2-Chloro-1,5-naphthyridine

Chemical Property:

• Vapor Pressure: 0.00605mmHg at 25°C
• Melting Point: 109-111 °C
• Refractive Index: 1.662
• Boiling Point: 281.5 °C at 760 mmHg
• PKA: 1.32±0.10(Predicted)
• Flash Point: 151 °C
• PSA: 25.78000
• Density: 1.349 g/cm³
• LogP: 2.28320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 164.0141259
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

≥99.0% ^*data from raw suppliers

2-Chloro-1,5-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=N2)Cl)N=C1

Technology Process of 2-Chloro-1,5-naphthyridine

There total 12 articles about 2-Chloro-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1,5-naphthyridine N-(1)-oxide (27305-48-2) → 2-chloro-1,5-naphthyridine (7689-62-5) + 4-chloro-1,5-naphthyridine (7689-63-6)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 8h;

DOI:10.1021/jm200386s

Reference yield:

1,5-naphthyridin-2(1H)-one (10261-82-2) → 2-chloro-1,5-naphthyridine (7689-62-5)

Guidance literature:

With trichlorophosphate; at 140 ℃;

Reference yield:

2-Hydroxy-1,5-naphthyridin (10261-82-2) → 2-chloro-1,5-naphthyridine (7689-62-5)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 5h;

upstream raw materials:

1,5-naphthyridin-2(1H)-one

1,5-naphthyridine N-⁽¹⁾-oxide

phosphorus pentachloride

trichlorophosphate

Downstream raw materials:

1,5-naphthyridin-2(1H)-one

N-(2-chloro-5-(1,5-naphthyridin-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

7-bromo-2-chloro-1,5-naphthyridine

C₂₁H₂₂N₄O₃

Refernces

• 1、 -. "NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF". . . Retrieved 2015/11/30.
• 2、 -. "HETEROBICYCLIC COMPOUNDS". Paragraph 1020. . Retrieved 2013/09/12.