2-Hydroxy-1,5-naphthyridine

Base Information

• Chemical Name: 2-Hydroxy-1,5-naphthyridine
• CAS No.: 10261-82-2
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 10261-82-2.mol

Synonyms:1,5-Naphthyridin-2-ol(6CI);1,5-Naphthyridine-2(1H)-one;2-Hydroxy-1,5-naphthyridine;

Chemical Property of 2-Hydroxy-1,5-naphthyridine

Chemical Property:

• Vapor Pressure: 2.4E-06mmHg at 25°C
• Melting Point: 258 °C
• Refractive Index: 1.602
• Boiling Point: 391.8 °C at 760 mmHg
• PKA: 11.29±0.20(Predicted)
• Flash Point: 190.8 °C
• PSA: 46.01000
• Density: 1.267g/cm³
• LogP: 1.33540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,5-Naphthyridin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,5-Naphthyridin-2(1H)-one is used as a reactant in the design of brain penetrant JNK inhibitors for prevention of neurodegeneration.

Technology Process of 2-Hydroxy-1,5-naphthyridine

There total 25 articles about 2-Hydroxy-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methoxy-[1,5]-naphthyridine (27017-69-2) → 1,5-naphthyridin-2(1H)-one (10261-82-2)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 2h;

Reference yield: 74.0%

6-Chloro-pyridin-3-ylamine (5350-93-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-Hydroxy-1,5-naphthyridin (10261-82-2)

Guidance literature:

With sulfuric acid; iron(II) sulfate; sodium 3-nitrobenzenesulfonate; at 130 - 160 ℃; for 6h; Concentration; Reagent/catalyst; Large scale;

Reference yield: 72.0%

ethyl 3-amino-2-pyridineacrylate (104829-97-2) → 1,5-naphthyridin-2(1H)-one (10261-82-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Heating;

upstream raw materials:

5-amino-2-hydroxypyridine

glycerol

6-Chloro-pyridin-3-ylamine

2-amino-1,5-naphthyridine

Downstream raw materials:

2-chloro-1,5-naphthyridine

3-nitro-1H-[1,5]naphthyridin-2-one

7-bromo-2-chloro-1,5-naphthyridine

C₂₁H₂₂N₄O₃

Refernces

• 1、 Van Dahm,Paudler. "-". . p. 3068. Retrieved 1975.
• 2、 -. "2-hydroxy-1,5-naphthyridine preparation method". Paragraph 0031; 0032. . Retrieved 2016/12/16.
• 3、 -. "1,5-NAPHTHYRIDINE DERIVATIVE OR SALT THEREOF". Paragraph 0263-0264. . Retrieved 2014/05/20.