N-(4-methoxy-2-methyl-phenyl)formamide

Base Information

• Chemical Name: N-(4-methoxy-2-methyl-phenyl)formamide
• CAS No.: 7402-54-2
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 7402-54-2.mol

Synonyms:4-Methoxy-2-methyl-formanilid;N-formyl-4-methoxy-2-methylaniline;

Chemical Property of N-(4-methoxy-2-methyl-phenyl)formamide

Chemical Property:

• Vapor Pressure: 6.43E-05mmHg at 25°C
• Boiling Point: 344.8°Cat760mmHg
• Flash Point: 162.3°C
• PSA: 38.33000
• Density: 1.127g/cm³
• LogP: 2.28080

Purity/Quality:

98%,99%, ^*data from raw suppliers

4'-METHOXY-2'-METHYLFORMANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-methoxy-2-methyl-phenyl)formamide

There total 2 articles about N-(4-methoxy-2-methyl-phenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

formic acid (64-18-6) + 2-methyl-4-methoxyaniline (102-50-1) → N-formyl-4-methoxy-2-methylaniline (7402-54-2)

Guidance literature:

With acetic anhydride; In dichloromethane; 16 h, r.t.; reflux, 4 h;

DOI:10.1021/ja00228a035

Reference yield:

→ N-formyl-4-methoxy-2-methylaniline (7402-54-2)

Guidance literature:

4-Methoxy-2-methyl-anilin, Dimethylformamid, Natriummethylat;

DOI:10.1021/jo01351a623

Reference yield: 74.0%

N-formyl-4-methoxy-2-methylaniline (7402-54-2) → 1-isocyano-4-methoxy-2-methylbenzene (1930-89-8)

Guidance literature:

With 4-methyl-morpholine; trichloromethyl chloroformate; In dichloromethane; at -30 ℃; for 1h;

DOI:10.1021/ja00228a035

upstream raw materials:

formic acid

2-methyl-4-methoxyaniline

Downstream raw materials:

1-isocyano-4-methoxy-2-methylbenzene

Refernces

• 1、 Kamer, Paul C. J.,Nolte, Roeland J. M.,Drenth, Wiendelt. "Screw Sense Selective Polymerization of Achiral Isocyanides Catalysed by Optically Active Nickel(II) Complexes". . p. 6818 - 6825. Retrieved 2007/10/02.