4-[3-(4-Butoxyphenoxy)propyl]morpholine;hydron;chloride

Base Information

• Chemical Name: 4-[3-(4-Butoxyphenoxy)propyl]morpholine;hydron;chloride
• CAS No.: 637-58-1
• Molecular Formula: C17H28ClNO3
• Molecular Weight: 329.867
• Hs Code.: 2934990002
• Mol file: 637-58-1.mol

Synonyms:AKOS026749901

Chemical Property of 4-[3-(4-Butoxyphenoxy)propyl]morpholine;hydron;chloride

Chemical Property:

• Appearance/Colour: White or off white crystalline powder
• Vapor Pressure: 1.7E-07mmHg at 25°C
• Melting Point: 181-183oC
• Boiling Point: 427 °C at 760 mmHg
• Flash Point: 123.5 °C
• PSA: 30.93000
• LogP: 3.70650
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 329.1757714
• Heavy Atom Count: 22
• Complexity: 248

Purity/Quality:

≥99% ^*data from raw suppliers

Pramoxine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CCCCOC1=CC=C(C=C1)OCCCN2CCOCC2.[Cl-]
• Description: Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.Pramoxine Hydrochloride is the hydrochloride salt form of pramoxine, It is a common, over-the-counter anti-itch ingredient that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.
• Uses: slows growth of unwanted facial hair Pramoxine Hydrochloride is used as a local anaesthetic and often in anti-itch formulations.
• Indications: Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a local anesthetic that is structurally similar to dyclonine and unrelated to the esteror amide-type compounds.Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within minutes. Duration of anesthesia is 2 to 4 hours.
• Therapeutic Function: Local anesthetic
• Clinical Use: Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemomhoids and other anorectal disorders.The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.

Technology Process of 4-[3-(4-Butoxyphenoxy)propyl]morpholine;hydron;chloride

There total 1 articles about 4-[3-(4-Butoxyphenoxy)propyl]morpholine;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.61%

3-morpholin-4-ylpropan-1-ol (4441-30-9) + 1-bromo-4-butoxybenzene (39969-57-8) → pramoxine hydrochloride (637-58-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h; Reflux;

upstream raw materials:

3-morpholin-4-ylpropan-1-ol

1-bromo-4-butoxybenzene

Refernces