4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE

Base Information

• Chemical Name: 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE
• CAS No.: 62039-92-3
• Molecular Formula: C8H7ClF3N
• Molecular Weight: 209.598
• Hs Code.: 2921499090
• Mol file: 62039-92-3.mol

Synonyms:1-[4-Chloro-3-(trifluoromethyl)phenyl]methanamine;3-Trifluoromethyl-4-chlorobenzylamine;4-Chloro-3-(trifluoromethyl)benzylamine;[4-Chloro-3-(trifluoromethyl)phenyl]methanamine;

Chemical Property of 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.294mmHg at 25°C
• Refractive Index: n 20/D 1.495
• Boiling Point: 222.9 °C at 760 mmHg
• PKA: 8.48±0.10(Predicted)
• Flash Point: 88.6 °C
• PSA: 26.02000
• Density: 1.353 g/cm³
• LogP: 3.51780
• Storage Temp.: Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-3-(trifluoromethyl)benzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,C
• Hazard Codes: T,C
• Statements: 25-36/38-43
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE

There total 2 articles about 4-CHLORO-3-(TRIFLUOROMETHYL)BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Trifluor-4-chlorbenzaldoxim → 4-chloro-3-(trifluoromethyl)benzylamine (62039-92-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00375a005

Reference yield:

→ 4-chloro-3-(trifluoromethyl)benzylamine (62039-92-3)

Guidance literature:

entspr. Phthalimid, N2H4;

Reference yield: 99.0%

2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid (885679-07-2) + 4-chloro-3-(trifluoromethyl)benzylamine (62039-92-3) → 2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(4-chloro-3-trifluoromethylbenzyl)pent-4-enamide (913563-89-0)

Guidance literature:

2-([(5-chloro-2-methoxyphenyl)sulfonyl]amino)pent-4-enoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

4-chloro-3-(trifluoromethyl)benzylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo060893z

Downstream raw materials:

2-(4-chloro-3-trifluoromethyl-benzylcarbamoyl)-5-fluoro-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

2-{[(5-chloro-2-methoxyphenyl)sulfonyl]amino}-N-(4-chloro-3-trifluoromethylbenzyl)pent-4-enamide

1-(4-chloro-3-trifluoromethyl-benzyl)-3-(7-hydroxy-naphthalen-1-yl)-urea

N-(2-(7-(4-chloro-3-(trifluoromethyl)benzylamino)-3-(4-methoxyphenyl)-2-oxoquinoxalin-1(2H)-yl)ethyl)acetamide

Refernces

• 1、 Meindl,Von Angerer,Schonenberger,Ruckdeschel. "Benzylamines: Synthesis and evaluation of antimycobacterial properties". . p. 1111 - 1118. Retrieved 2007/10/02.