fluorophen

Base Information

• Chemical Name: fluorophen
• CAS No.: 86495-14-9
• Molecular Formula: C₂₂H₂₆FNO
• Molecular Weight: 339.453
• Mol file: 86495-14-9.mol

Synonyms:2,6-Methano-3-benzazocin-8-ol,3-[2-(4-fluorophenyl)ethyl]-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2a,6a,11R*)- (9CI); 2,6-Methano-3-benzazocin-8-ol,3-[2-(4-fluorophenyl)ethyl]-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2a,6a,11R*)-(?à)-; (?à)-5,9a-Dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan;(?à)-Fluorophen

Chemical Property of fluorophen

Chemical Property:

• Vapor Pressure: 2.97E-09mmHg at 25°C
• Boiling Point: 464.6°C at 760 mmHg
• Flash Point: 234.8°C
• PSA: 23.47000
• Density: 1.142g/cm³
• LogP: 4.23610

Purity/Quality:

99%一级, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of fluorophen

There total 3 articles about fluorophen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (52079-30-8) → fluorophen (86495-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.06 g / K₂CO₃ / methanol

2: 1.) B₂H₆, 2.) 37percent aq. HCl / 1.) THF, reflux, 2 h, 2.) MeOH, heating, 1 h

With hydrogenchloride; potassium carbonate; diborane; In methanol;

DOI:10.1021/jm00365a017

Reference yield:

4-Fluorophenylacetyl chloride (459-04-1) → fluorophen (86495-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.06 g / K₂CO₃ / methanol

2: 1.) B₂H₆, 2.) 37percent aq. HCl / 1.) THF, reflux, 2 h, 2.) MeOH, heating, 1 h

With hydrogenchloride; potassium carbonate; diborane; In methanol;

DOI:10.1021/jm00365a017

Reference yield:

2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone (86436-93-3) → fluorophen (86495-14-9)

Guidance literature:

With hydrogenchloride; diborane; Yield given. Multistep reaction; 1.) THF, reflux, 2 h, 2.) MeOH, heating, 1 h;

DOI:10.1021/jm00365a017

upstream raw materials:

2-(4-Fluoro-phenyl)-1-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-ethanone

(+/-)-cis-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan

4-Fluorophenylacetyl chloride

Refernces