Technology Process of Pipermethystine
There total 5 articles about Pipermethystine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
DOI:10.1021/ol010183+
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 80 percent / RuCl2(PCy3)2CHPh / CH2Cl2 / 12 h / Heating
2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C
2.2: 94 percent / tetrahydrofuran; hexane / 0.17 h / -78 °C
3.1: 91 percent / MCPBA / CH2Cl2 / 15 h / 20 °C
4.1: 99 percent / t-BuOK / 2-methyl-propan-2-ol / 20 °C
5.1: 98 percent / TMSOTf / CH2Cl2 / 0.08 h / 0 °C
With
Grubbs catalyst first generation; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol010183+
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 94 percent / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.1: 91 percent / MCPBA / CH2Cl2 / 15 h / 20 °C
3.1: 99 percent / t-BuOK / 2-methyl-propan-2-ol / 20 °C
4.1: 98 percent / TMSOTf / CH2Cl2 / 0.08 h / 0 °C
With
n-butyllithium; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol010183+
