3-deazaadenine

Base Information

• Chemical Name: 3-deazaadenine
• CAS No.: 6811-77-4
• Molecular Formula: C6H6 N4
• Molecular Weight: 134.14
• Hs Code.: 2933990090
• Mol file: 6811-77-4.mol

Synonyms:1H-Imidazo[4,5-c]pyridin-4-amine(9CI); 1H-Imidazo[4,5-c]pyridine, 4-amino- (7CI,8CI); 3-Deazaadenine

Chemical Property of 3-deazaadenine

Chemical Property:

• Vapor Pressure: 2.73E-11mmHg at 25°C
• Boiling Point: 529.3°C at 760 mmHg
• PKA: 11.37±0.40(Predicted)
• Flash Point: 307.3°C
• PSA: 67.59000
• Density: 1.48g/cm³
• LogP: 1.12130
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

3-Deazaadenine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-deazaadenine

There total 42 articles about 3-deazaadenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-benzyl-3H-imidazo[4,5-c]pyridin-4-amine → 4-amino-1H-imidazo[4,5-b]pyrimidine (6811-77-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; for 5h;

Reference yield: 99.0%

7H-imidazo[4,5-c]tetrazo[1,5-a]pyridine (1207615-07-3) → 3-deazaadenine (6811-77-4)

Guidance literature:

7H-imidazo[4,5-c]tetrazo[1,5-a]pyridine; With hydrogenchloride; palladium 10% on activated carbon; In water; for 0.166667h;

With hydrogen; In water; for 36h; under 2280.15 Torr; Product distribution / selectivity;

Reference yield: 90.0%

4-chloro-1H-imidazo[4,5-c]pyridine (2770-01-6) → 3-deazaadenine (6811-77-4)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 140 ℃; for 2h; Temperature; Microwave irradiation; Inert atmosphere;

DOI:10.3762/bjoc.12.250

upstream raw materials:

4-chloro-1⁽³⁾H-imidazo[4,5-c]pyridine; hydrochloride

4-Amino-1-(2,3-dideoxy-β-D-glyceropentofuranosyl)-1H-imidazo<4,5-c>pyridine

4-Amino-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-imidazo<4,5-c>pyridine

4-azidoimidazo[4,5-c]pyridine

Downstream raw materials:

4-amino-1-[2'-deoxy-3',5'-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl]-7-nitro-1H-imidazo[4,5-c]pyridine

4-amino-3-[2'-deoxy-3',5'-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl]-7-nitro-3H-imidazo[4,5-c]pyridine

cyclic ester of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)-3-deazaadenine

9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl)-3-deazaadenine

Refernces

• 1、 Bereiter, Raphael,Himmelsto?, Maximilian,Renard, Eva,Mairhofer, Elisabeth,Egger, Michaela,Breuker, Kathrin,Kreutz, Christoph,Ennifar, Eric,Micura, Ronald. "Impact of 3-deazapurine nucleobases on RNA properties". . p. 4281 - 4293. Retrieved 2021/06/01.
• 2、 -. "Pharmaceutical composition for treating hyperplasia of mammary glands as well as preparation method and application of pharmaceutical composition". Paragraph 0022; 0039; 0040; 0041. . Retrieved 2018/09/26.