methyl 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoate

Base Information

• Chemical Name: methyl 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoate
• CAS No.: 64552-20-1
• Molecular Formula: C₁₄H₁₄N₂O₅
• Molecular Weight: 290.276
• Mol file: 64552-20-1.mol

Synonyms:NSC117491

Chemical Property of methyl 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoate

Chemical Property:

• Vapor Pressure: 8.23E-12mmHg at 25°C
• Boiling Point: 542°Cat760mmHg
• Flash Point: 281.6°C
• Density: 1.392g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoate

There total 3 articles about methyl 5-amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-phthalimidoglutaramic acid (7607-72-9,2110-19-2,174591-46-9) → N2,N2-phthaloyl-glutamine-methyl ester (64552-20-1,65104-01-0)

Guidance literature:

With methanol; diethyl ether;

DOI:10.1021/ja01162a031

Reference yield:

N-phthaloyl glutamic acid α-methyl ester (150823-38-4) → N2,N2-phthaloyl-glutamine-methyl ester (64552-20-1,65104-01-0)

Guidance literature:

With diethyl ether; phosphorus pentachloride; Behandeln des Reaktionsprodukts in Aether mit Ammoniak;

DOI:10.1021/ja01162a031

Reference yield:

N-phthaloylglutamic acid anhydride (3343-28-0,3085-92-5) → N2,N2-phthaloyl-glutamine-methyl ester (64552-20-1,65104-01-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol

2: diethyl ether; phosphorus (V)-chloride / Behandeln des Reaktionsprodukts in Aether mit Ammoniak

With methanol; diethyl ether; phosphorus pentachloride;

DOI:10.1021/ja01162a031

upstream raw materials:

diazomethane

2-phthalimidoglutaramic acid

N-phthaloyl glutamic acid α-methyl ester

N-phthaloylglutamic acid anhydride