leukotriene E4

Base Information Edit

Chemical Name:leukotriene E4
CAS No.:75715-89-8
Molecular Formula:C23H37 N O5 S
Molecular Weight:439.61
Hs Code.:
UNII:8EYT8ATL7G
ChEMBL ID:CHEMBL509456
DSSTox Substance ID:DTXSID20897510
Metabolomics Workbench ID:2562
NCI Thesaurus Code:C129009
Nikkaji Number:J264.600E
Pharos Ligand ID:AVT4X7W62AXM
Wikidata:Q2705859
Wikipedia:Leukotriene_E4
Mol file:75715-89-8.mol

Synonyms:Leukotriene E;Leukotriene E 4;Leukotriene E-4;Leukotriene E4;Leukotrienes E;LTE4

Suppliers and Price of leukotriene E4

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LeukotrieneE4
10mg
$ 10240.00

Cayman Chemical
Leukotriene E4 ≥97%
100μg
$ 280.00

Cayman Chemical
Leukotriene E4 ≥97%
50μg
$ 149.00

Cayman Chemical
Leukotriene E4 MaxSpec? Standard ≥95%
10μg
$ 121.00

Cayman Chemical
Leukotriene E4 ≥97%
25μg
$ 79.00

American Custom Chemicals Corporation
LEUKOTRIENE E4 (IN ETOH) 95.00%
100μG
$ 802.37

Total 3 raw suppliers

Chemical Property of leukotriene E4 Edit

Chemical Property:

Vapor Pressure:4.63E-21mmHg at 25°C
Boiling Point:674.1°C at 760 mmHg
Flash Point:361.5°C
PSA：146.15000
Density:1.132g/cm³
LogP:5.01140
Storage Temp.:−20°C
XLogP3:2.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:18
Exact Mass:439.23924445
Heavy Atom Count:30
Complexity:586

Purity/Quality:

99% ^*data from raw suppliers

LeukotrieneE4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F,T
Statements: 11
Safety Statements: 7-16-23-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N
Isomeric SMILES:CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N
Uses Leukotriene E4 is a metabolite of Arachidonic acid (A765000) via the lipoxygenase pathway, chemically related to the prostaglandins and thromboxanes. The name leukotrienes was applied because of their origin in leukocytes and their conjugated triene structures.

Technology Process of leukotriene E4

There total 27 articles about leukotriene E4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 74448-22-9
leukotriene E₄ dimethyl ester

: 75715-89-8
leukotriene E4

Guidance literature:: With potassium carbonate; In methanol; water; at 0 ℃; for 3.5h;
DOI:10.1002/1099-0690(200009)2000:17<2991::AID-EJOC2991>3.0.CO;2-H

Reference yield:

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 75443-89-9,75715-88-7,75715-89-8,82468-17-5,84823-21-2,84823-22-3,84823-23-4,84823-24-5,84823-25-6,92009-31-9,130010-34-3,130010-35-4
(7E,9E,11Z,14Z)-(5R,6S)-6-(2-Amino-2-carboxy-ethylsulfanyl)-5-hydroxy-icosa-7,9,11,14-tetraenoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: dimsyl sodium

2: PhSSPh / cyclohexane / 4 h / Irradiation

4: m-CPBA / CH₂Cl₂

5: NaIO₄, H₂O / acetic acid

6: 84 percent / benzene / Heating

7: 34 percent / benzene / Heating

8: 56 percent

9: (C₂H₅)3N / methanol

10: K₂CO₃ / methanol; H₂O

With sodium periodate; water; sodium methylsulfinylmethanide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; diphenyldisulfane; In methanol; dichloromethane; cyclohexane; water; acetic acid; benzene;
DOI:10.1016/S0040-4039(01)82844-6