Oxanosine

Base Information

• Chemical Name: Oxanosine
• CAS No.: 80394-72-5
• Molecular Formula: C10H12N4O6
• Molecular Weight: 284.228
• Nikkaji Number: J33.891E
• Metabolomics Workbench ID: 98257
• Mol file: 80394-72-5.mol

Synonyms:5-amino-3-beta-D-ribofuranosyl-3H-imidazo(4,5-d)(1,3)oxazin-7-one;oxanosine

Chemical Property of Oxanosine

Chemical Property:

• Vapor Pressure: 3.75E-24mmHg at 25°C
• Melting Point: 199 °C(Solv: water (7732-18-5))
• Boiling Point: 758.1°Cat760mmHg
• PKA: 13.17±0.70(Predicted)
• Flash Point: 412.3°C
• PSA: 156.86000
• Density: 2.23g/cm³
• LogP: -1.84060
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 284.07568412
• Heavy Atom Count: 20
• Complexity: 446

Purity/Quality:

99%min ^*data from raw suppliers

OXANOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(OC2=O)N
• Isomeric SMILES: C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(OC2=O)N

Technology Process of Oxanosine

There total 3 articles about Oxanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

N1-hydroxyinosine (5383-06-2) → 5-amino-3-β-D-ribofuranosyl-3H-imidaso<4,5-d><1,3>oxazin-7-one (80394-72-5) + Inosine (58-63-9) + xanthosine (146-80-5)

Guidance literature:

In water; for 2h; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(98)01605-0

Reference yield:

G (118-00-3) → 5-amino-3-β-D-ribofuranosyl-3H-imidaso<4,5-d><1,3>oxazin-7-one (80394-72-5) + 2-chloroinosine (13276-43-2) + xanthosine (146-80-5)

Guidance literature:

With sodium acetate; sodium chloride; sodium nitrite; In water; at 37 ℃; for 2h; pH=3.2; Product distribution;

DOI:10.1016/S0968-0896(01)00173-0

Reference yield:

C10H11N6O6(1-) → 5-amino-3-β-D-ribofuranosyl-3H-imidaso<4,5-d><1,3>oxazin-7-one (80394-72-5) + 2-chloroinosine (13276-43-2) + xanthosine (146-80-5)

Guidance literature:

With phosphate buffer; sodium chloride; In water; at 37 ℃; for 1h; pH=7.4; Product distribution;

DOI:10.1016/S0968-0896(01)00173-0

upstream raw materials:

N¹-hydroxyinosine

G

Refernces

• 1、 De Napoli, Lorenzo,Di Fabio, Giovanni,Messere, Anna,Montesarchio, Daniela,Piccialli, Gennaro,Varra, Michela. "A new synthesis of oxanosine and 2'-deoxyoxanosine". . p. 7397 - 7400. Retrieved 2007/10/03.