PYRAZINE-N,N'-DIOXIDE

Base Information

• Chemical Name: PYRAZINE-N,N'-DIOXIDE
• CAS No.: 2423-84-9
• Molecular Formula: C4H4 N2 O2
• Molecular Weight: 112.088
• Hs Code.: 2933990090
• Mol file: 2423-84-9.mol

Synonyms:Pyrazinedioxide (6CI); Pyrazine N,N'-dioxide; Pyrazine di-N-oxide

Chemical Property of PYRAZINE-N,N'-DIOXIDE

Chemical Property:

• Melting Point: 310°C (dec.)
• Boiling Point: °Cat760mmHg
• PKA: 2.11±0.10(Predicted)
• Flash Point: °C
• PSA: 50.92000
• Density: g/cm³
• LogP: 0.54360

Purity/Quality:

98%Min ^*data from raw suppliers

Pyrazine1,4-Dioxide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRAZINE-N,N'-DIOXIDE

There total 2 articles about PYRAZINE-N,N'-DIOXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,4-pyrazine (290-37-9) → Pyrazin-N.N'-dioxyd (2423-84-9)

Guidance literature:

With acetonitrile complex of hypofluorous acid; In dichloromethane; at 0 ℃;

DOI:10.1021/acs.orglett.7b02310

Reference yield:

→ Pyrazin-N.N'-dioxyd (2423-84-9)

Guidance literature:

Pyrazin, H2O2;

Reference yield: 95.0%

Pyrazin-N.N'-dioxyd (2423-84-9) + methyl iodide (74-88-4) → N-methylpyrazinium iodide (6277-35-6)

Guidance literature:

In ethanol; for 5h; Heating;

upstream raw materials:

1,4-pyrazine

Downstream raw materials:

pyrazinamide

N-methylpyrazinium iodide

2,3-dichloropyrazine

2,6-dichloropyrazine

Refernces

• 1、 Rozen, Shlomo,Shaffer, Avshalom. "Synthesis of N,N-Dioxopyridazines". supporting information. p. 4707 - 4709. Retrieved 2017/09/23.
• 2、 Acree Jr.,Powell, Joyce R.,Tucker, Sheryl A.,Ribeiro da Silva, Maria D.M.C.,Matos, M. Agostinha R.,Goncalves,Santos,Morais,Pilcher. "Thermochemical and Theoretical Study of Some Quinoxaline 1,4-Dioxides and of Pyrazine 1,4-Dioxide". . p. 3722 - 3726. Retrieved 2007/10/03.