Chlorproethazine

Base Information

• Chemical Name: Chlorproethazine
• CAS No.: 84-01-5
• Molecular Formula: C19H23 Cl N2 S
• Molecular Weight: 346.924
• Hs Code.: 2934300000
• European Community (EC) Number: 201-510-8
• UNII: 960NX27Z07
• DSSTox Substance ID: DTXSID80232882
• Nikkaji Number: J4.889E
• Wikipedia: Chlorproethazine
• Wikidata: Q610084
• NCI Thesaurus Code: C79580
• Metabolomics Workbench ID: 154195
• ChEMBL ID: CHEMBL52125
• Mol file: 84-01-5.mol

Synonyms:3-chloro-10-(3-diethylaminopropyl)phenothiazine;chlorproethazine;chlorproethazine hydrochloride;chlorproethazine monohydrochloride;Neuriplège

Chemical Property of Chlorproethazine

Chemical Property:

• Melting Point: 153-156°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 211°C (rough estimate)
• PSA: 31.78000
• Density: 1.1206 (rough estimate)
• LogP: 5.73960
• Storage Temp.: -20?C Freezer
• XLogP3: 5.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 346.1270476
• Heavy Atom Count: 23
• Complexity: 363

Purity/Quality:

99% ^*data from raw suppliers

CHLORPROETHAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
• Uses: MIchlorproethazine.
• Therapeutic Function: Muscle relaxant; Tranquilizer

Technology Process of Chlorproethazine

There total 6 articles about Chlorproethazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chloro-10H-phenothiazin-10-yl)propanonitrile (4414-83-9) + diethylamine (109-89-7) → chlorproethazine (84-01-5)

Guidance literature:

With nickel; benzene; at 88 - 97 ℃; under 45601.5 Torr; Hydrogenation;

Reference yield:

→ chlorproethazine (84-01-5)

Guidance literature:

With copper; potassium carbonate; N,N-dimethyl-formamide;

Reference yield:

3-chlorodiphenylamine (101-17-7) → chlorproethazine (84-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; sulfur

2: NaNH₂; xylene

With iodine; sulfur; sodium amide; xylene;

upstream raw materials:

2-chlorophenothiazine

3-diethylaminopropyl chloride

3-(2-chloro-10H-phenothiazin-10-yl)propanonitrile

diethylamine

Refernces