7-Methoxybenzofuran-2-carboxylic acid

Base Information

• Chemical Name: 7-Methoxybenzofuran-2-carboxylic acid
• CAS No.: 4790-79-8
• Molecular Formula: C10H8O4
• Molecular Weight: 192.171
• Hs Code.: 29321900
• Mol file: 4790-79-8.mol

Synonyms:Coumarilicacid, 7-methoxy- (6CI);2-Carboxy-7-methoxybenzofuran;7-Methoxy-1-benzofuran-2-carboxylic acid;7-Methoxy-2-benzofurancarboxylicacid;7-Methoxycoumarilic acid;

Chemical Property of 7-Methoxybenzofuran-2-carboxylic acid

Chemical Property:

• Appearance/Colour: beige fine crystals
• Vapor Pressure: 1.43E-05mmHg at 25°C
• Melting Point: 221-223 °C(lit.)
• Refractive Index: 1.5430 (estimate)
• Boiling Point: 352.4 °C at 760 mmHg
• PKA: 3.05±0.30(Predicted)
• Flash Point: 166.9 °C
• PSA: 59.67000
• Density: 1.345 g/cm³
• LogP: 2.13960

Purity/Quality:

99% ^*data from raw suppliers

7-Methoxybenzofuran-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 7-Methoxy-2-benzofurancarboxylic acid may be used in the synthesis of fluorous counterpart of the Marshall resin, 4-(1H,1H,2H,2H-perfluorodecylsulfanyl)phenol.

Technology Process of 7-Methoxybenzofuran-2-carboxylic acid

There total 12 articles about 7-Methoxybenzofuran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 7-methoxybenzofuran-2-carboxylic acid (4790-79-8)

Guidance literature:

3-methoxy-2-hydroxybenzaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 150 ℃;

With sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1080/14756366.2018.1491564

Reference yield: 70.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + chloroacetic acid ethyl ester (105-39-5) → 7-methoxybenzofuran-2-carboxylic acid (4790-79-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 3h; Heating;

Reference yield: 46.0%

→ 7-methoxybenzofuran-2-carboxylic acid (4790-79-8)

Guidance literature:

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

ethyl bromoacetate

ethyl 7-methoxybenzofuran-2-carboxylate

chloroacetic acid ethyl ester

Downstream raw materials:

2-carbomethoxy-7-methoxybenzofuran

2-hydroxymethyl-7-methoxy-benzofuran

7-methoxy-benzofuran-2-carboxylic acid 4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decylsulfanyl)-phenyl ester

Refernces

• 1、 Hu, Naifu,Jung, Hoimin,Zheng, Yu,Lee, Juhyeong,Zhang, Lilu,Ullah, Zakir,Xie, Xiulan,Harms, Klaus,Baik, Mu-Hyun,Meggers, Eric. "Catalytic Asymmetric Dearomatization by Visible-Light-Activated [2+2] Photocycloaddition". supporting information. p. 6242 - 6246. Retrieved 2018/05/03.
• 2、 Hiremathad, Asha,Chand, Karam,Keri, Rangappa S.. "Development of coumarin–benzofuran hybrids as versatile multitargeted compounds for the treatment of Alzheimer’s Disease". . p. 1497 - 1503. Retrieved 2018/07/31.