ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE
• CAS No.: 50551-58-1
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Hs Code.: 29321900
• Mol file: 50551-58-1.mol

Synonyms:2-Ethoxycarbonyl-7-methoxybenzofuran;7-Methoxy-2-benzofurancarboxylic acid ethyl ester;Ethyl 7-methoxycoumarilate;7-Methoxybenzofuran-2-carboxylic acid ethyl ester;

Chemical Property of ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE

Chemical Property:

• Appearance/Colour: yellow crystals
• Vapor Pressure: 0.000418mmHg at 25°C
• Melting Point: 85-90 °C
• Refractive Index: 1.557
• Boiling Point: 316.2 °C at 760 mmHg
• Flash Point: 145 °C
• PSA: 48.67000
• Density: 1.192 g/cm³
• LogP: 2.61810

Purity/Quality:

99% ^*data from raw suppliers

ethyl7-methoxybenzofuran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE

There total 9 articles about ETHYL 7-METHOXYBENZOFURAN-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-ethoxycarbonylmethoxy-3-methoxybenzaldehyde (70076-67-4) → ethyl 7-methoxybenzofuran-2-carboxylate (50551-58-1)

Guidance literature:

With P(MeNCH₂CH₂)3N; In ethanol; at 70 ℃; for 3h;

DOI:10.1055/s-2001-13377

Reference yield: 84.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + chloroacetic acid ethyl ester (105-39-5) → ethyl 7-methoxybenzofuran-2-carboxylate (50551-58-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1002/cmdc.202000258

Reference yield: 75.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + ethyl bromoacetate (105-36-2) → ethyl 7-methoxybenzofuran-2-carboxylate (50551-58-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 135 - 140 ℃;

DOI:10.1080/14756366.2019.1689237

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

Diethyl 2-bromomalonate

ethanol

chloroacetic acid ethyl ester

Downstream raw materials:

2-hydroxymethyl-7-methoxy-benzofuran

7-methoxybenzofuran-2-carboxylic acid

Refernces

• 1、 Cardoso, Sandra M.,Chand, Karam,Chaves, Sílvia,Fancellu, Gaia,Orlandini, Elisabetta,Piemontese, Luca,Santos, M. Amélia,Silva, Diana F.,Tomás, Daniel. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". . p. 211 - 226. Retrieved 2019/11/29.
• 2、 Hiremathad, Asha,Chand, Karam,Keri, Rangappa S.. "Development of coumarin–benzofuran hybrids as versatile multitargeted compounds for the treatment of Alzheimer’s Disease". . p. 1497 - 1503. Retrieved 2018/07/31.