TIMTEC-BB SBB003449

Base Information

• Chemical Name: TIMTEC-BB SBB003449
• CAS No.: 6640-65-9
• Molecular Formula: C9H10N2O4
• Molecular Weight: 210.189
• Mol file: 6640-65-9.mol

Synonyms:4-Nitro-benzoesaeure-(2-hydroxy-aethylamid);N-(2-Hydroxyphenyl)(4-nitrophenyl)carboxamide;4-nitro-benzoic acid-(2-hydroxy-ethylamide);4-Nitro-benzoesaeure-(2-hydroxy-anilid);N-(2-Hydroxyethyl)-4-nitrobenzamide;N-(p-nitrobenzoyl)-o-aminophenol;N-(2-Hydroxy-phenyl)-4-nitro-benzamide;N-(2-Hydroxy-ethyl)-4-nitro-benzoesaeureamid;4-nitro-benzoic acid-(2-hydroxy-anilide);N-o-Hydroxyphenyl-p-nitrobenzamid;2--aethanol;N-(2-Hydroxyaethyl)-p-nitrobenzamid;

Chemical Property of TIMTEC-BB SBB003449

Chemical Property:

• Vapor Pressure: 1.23E-09mmHg at 25°C
• Boiling Point: 470°Cat760mmHg
• Flash Point: 238°C
• PSA: 95.15000
• Density: 1.35g/cm³
• LogP: 1.23100

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Hydroxyethyl)-4-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TIMTEC-BB SBB003449

There total 11 articles about TIMTEC-BB SBB003449 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-nitro-benzoyl chloride (122-04-3) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-4-nitrobenzamide (6640-65-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1039/b818310d

Reference yield: 95.0%

N-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-nitrobenzamide → N-(2-hydroxyethyl)-4-nitrobenzamide (6640-65-9)

Guidance literature:

With Povidone-Iodine; In methanol; at 30 ℃; for 1h;

DOI:10.1016/j.tetlet.2019.05.059

Reference yield: 94.0%

4-nitrobenzoic acid methyl ester (619-50-1) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-4-nitrobenzamide (6640-65-9)

Guidance literature:

In toluene; at 96 ℃; for 3h;

upstream raw materials:

4-nitro-benzoyl chloride

ethanolamine

1-(p-nitrobenzoyl)aziridine

4-nitrophenyl 4-nitrobenzoate

Downstream raw materials:

1-chlorocarbonyloxy-2-(4-nitro-benzoylamino)-ethane

N-(2-Hydroxyethyl)-4-aminobenzamide

2-(4-Nitrophenyl)-4,5-dihydrooxazole

3-(4-nitro-benzoyl)-oxazolidine

Refernces

• 1、 Ramos, Robin,Zimbron, Jérémy M.,Thorimbert, Serge,Chamoreau, Lise-Marie,Munier, Annie,Botuha, Candice,Karaiskou, Anthi,Salmain, Michèle,Sobczak-Thépot, Jo?lle. "Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes". supporting information. p. 17635 - 17641. Retrieved 2020/12/30.
• 2、 -. "High-planarity diamine monomer containing fluorene or fluorenone structure and synthesis method and application thereof". Paragraph 0108; 0109; 0110. . Retrieved 2016/10/08.