HARMOL

Base Information

• Chemical Name: HARMOL
• CAS No.: 487-03-6
• Molecular Formula: C12H10 N2 O
• Molecular Weight: 198.224
• Hs Code.: 2933990090
• Mol file: 487-03-6.mol

Synonyms:Harmol(6CI,7CI); NSC 72292

Chemical Property of HARMOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 231°C
• Boiling Point: 552.7°Cat760mmHg
• PKA: pKa 7.90(H2O) (Uncertain);9.47 (Uncertain);15.75 (Uncertain)
• Flash Point: 255°C
• PSA: 48.91000
• Density: 1.33g/cm³
• LogP: 2.73010
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Harmol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

Useful:

Technology Process of HARMOL

There total 15 articles about HARMOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

harmine (442-51-3) → harmol (487-03-6)

Guidance literature:

With water; hydrogen bromide; acetic acid; for 15h; Reflux; Inert atmosphere;

Reference yield: 23.0%

7-acetyloxy-1-methyl-9H-pyrido[3,4-b]indole (257938-78-6) → harmol (487-03-6) + 8-chloro-harmol + 6-chloro-harmol

Guidance literature:

With N-chloro-succinimide; at 22 ℃;

DOI:10.1002/jhet.5570400304

Reference yield:

({[Mg4(adipate)4(N,N-dimethylacetamide)(H2O)]*5(N,N-dimethylacetamide)*2methanol*4H2O}) → 3-hydroxyxanthen-9-one (3722-51-8) + harmol (487-03-6) + stilbene (588-59-0) + o-tolidin (119-93-7) + trindane (1206-79-7)

Guidance literature:

at 450 - 550 ℃;

DOI:10.1021/ja401869h

upstream raw materials:

harmine

hydrogenchloride

7-acetyloxy-1-methyl-9H-pyrido[3,4-b]indole

harmaline

Downstream raw materials:

harmane

Tetrahydroharmol

7-deuteromethoxy-1-methyl-9H-pyrido[3,4-b]indole

Refernces

• 1、 Kumar, Kunal,Wang, Peng,Swartz, Ethan A.,Khamrui, Susmita,Secor, Cody,Lazarus, Michael B.,Sanchez, Roberto,Stewart, Andrew F.,DeVita, Robert J.. "Structure–activity relationships and biological evaluation of 7-substituted harmine analogs for human β-cell proliferation". . . Retrieved 2020.
• 2、 Ponce, Maria A.,Tarzi, Olga I.,Erra-Balsells, Rosa. "Synthesis and isolation of chloro-β-carbolines obtained by chlorination of β-carboline alkaloids in solution and in solid state". . p. 419 - 426. Retrieved 2003.
• 3、 -. "?-CARBOLINE, DIHYDRO-?-CARBOLINE AND TETRAHYDRO-?-CARBOLINE ALKALOID DERIVATIVES AND PREPARATION METHODS SAME AND USE IN ASPECTS OF PREVENTING AND TREATING PLANT VIRUSES, FUNGICIDES AND INSECTICIDES". Paragraph 0115-0117. . Retrieved 2016/11/28.