Harmine-d3

Base Information

• Chemical Name: Harmine-d3
• CAS No.: 1216704-96-9
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 215.227
• Mol file: 1216704-96-9.mol

Synonyms:Harmine-d3;1-Methyl-7-(Methoxy-d3)-β -carboline;7-(Methoxy-d3)-1-Methyl-9H-pyrido[3,4-b]indole

Chemical Property of Harmine-d3

Chemical Property:

• PSA: 37.91000
• LogP: 3.03310
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

Harmine-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled CNS stimulant.

Technology Process of Harmine-d3

There total 2 articles about Harmine-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

iodomethane-d3 (865-50-9) + harmol (487-03-6) → 7-deuteromethoxy-1-methyl-9H-pyrido[3,4-b]indole (1216704-96-9)

Guidance literature:

harmol; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

iodomethane-d3; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

harmine (442-51-3) → 7-deuteromethoxy-1-methyl-9H-pyrido[3,4-b]indole (1216704-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; hydrogen bromide / 10 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 12 h / 20 °C

With hydrogen bromide; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

harmine

iodomethane-d3

harmol

Refernces