1,1,2-Triphenylethanol

Base Information

• Chemical Name: 1,1,2-Triphenylethanol
• CAS No.: 4428-13-1
• Molecular Formula: C20H18O
• Molecular Weight: 274.362
• Hs Code.: 2906299090
• European Community (EC) Number: 224-614-5
• NSC Number: 56476
• DSSTox Substance ID: DTXSID60871076
• Nikkaji Number: J205.805G
• Wikipedia: Triphenylethanol
• Wikidata: Q28456694
• ChEMBL ID: CHEMBL118088
• Mol file: 4428-13-1.mol

Synonyms:1,1,2-Triphenylethanol;4428-13-1;1,2-Triphenylethanol;1,1,2-Triphenyl-ethanol;1,1,2-Triphenylethan-1-ol;Benzeneethanol, .alpha.,.alpha.-diphenyl-;triphenylethanol;NSC56476;Benzyldiphenylcarbinol;Ethanol,1,2-triphenyl-;NCIOpen2_002305;Benzhydrol, .alpha.-benzyl-;SCHEMBL912792;CHEMBL118088;Benzeneethanol,.alpha.-diphenyl-;alpha,alpha-Diphenylbenzeneethanol;DTXSID60871076;Phenethyl alcohol,.alpha.-diphenyl-;NSC-56476;AKOS024323338;1-BENZYL-1,1-DIPHENYLMETHANOL;FT-0655235;A826526

Chemical Property of 1,1,2-Triphenylethanol

Chemical Property:

• Vapor Pressure: 4.81E-07mmHg at 25°C
• Melting Point: 89.5°C
• Refractive Index: 1.619
• Boiling Point: 397.9 °C at 760 mmHg
• Flash Point: 153.1 °C
• PSA: 20.23000
• Density: 1.122 g/cm³
• LogP: 4.16520
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 274.135765193
• Heavy Atom Count: 21
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

1,1,2-TRIPHENYLETHANOL Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C2=CC=CC=C2)(C3=CC=CC=C3)O

Technology Process of 1,1,2-Triphenylethanol

There total 74 articles about 1,1,2-Triphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzophenone (119-61-9) + benzyl chloride (100-44-7) → 1,1,2-Triphenylethanol (4428-13-1)

Guidance literature:

benzyl chloride; With lithium naphthalenide; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Flow reactor;

benzophenone; Inert atmosphere; Flow reactor;

DOI:10.1039/c5ob00958h

Reference yield: 92.0%

benzophenone (119-61-9) + o-(benzyldimethylsilyl)benzyl alcohol (201050-00-2) → 1,1,2-Triphenylethanol (4428-13-1)

Guidance literature:

o-(benzyldimethylsilyl)benzyl alcohol; With n-butyllithium; In hexanes; diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

benzophenone; In hexanes; diethyl ether; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.09.127

Reference yield: 86.0%

bromobenzene (108-86-1,52753-63-6) + Ethyl 2-phenylethanoate (101-97-3) → 1,1,2-Triphenylethanol (4428-13-1)

Guidance literature:

With magnesium; copper(II) oxide; In tetrahydrofuran; at 65 ℃; for 4h; chemoselective reaction;

DOI:10.1016/j.tetlet.2013.12.042

upstream raw materials:

phenyl benzyl ketone

benzophenone

phenylmagnesium bromide

benzyl potassium

Downstream raw materials:

Triphenylethylene

nitro-tris-(4-nitro-phenyl)-ethene

nitro-triphenyl-ethene

2-bromo-1,1,2-triphenyl-ethanol

Refernces

• 1、 Okubo, Masao,Morigami, Yoshiaki,Suenaga, Reiko. "Evidence for Electron-transfer Process in Abnormal Gringard Reactions. Enolization and α-Diketone Formation". . p. 3029 - 3030. Retrieved 1980.
• 2、 Ferguson, George,Gallagher, John F.,Glidewell, Christopher,Zakaria, Choudhury M.. "O-H...?(arene) Intermolecular Hydrogen Bonding in the Structure of 1,1,2-Triphenylethanol". . p. 70 - 73. Retrieved 1994.
• 3、 Ferguson, George,Gallagher, John F.,Glidewell, Christopher,Zakaria, Choudhury M.. "Hydrogen bonding in ferrocene derivatives: crystal structure of racemic ferrocenyl(phenyl)methanol". . p. 95 - 102. Retrieved 1994.
• 4、 Berger, Anna Lucia,Donabauer, Karsten,K?nig, Burkhard. "Photocatalytic Barbier reaction-visible-light induced allylation and benzylation of aldehydes and ketones". . p. 7230 - 7235. Retrieved 2018/10/02.
• 5、 Wang, Haining,Dai, Xi-Jie,Li, Chao-Jun. "Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds". . p. 374 - 378. Retrieved 2017/04/03.