(3beta,4alpha,8alpha,12xi)-4,15-bis(acetyloxy)-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate

Base Information

• Chemical Name: (3beta,4alpha,8alpha,12xi)-4,15-bis(acetyloxy)-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate
• CAS No.: 97373-18-7
• Molecular Formula: C₂₄H₃₄O₁₀
• Molecular Weight: 482.528
• Mol file: 97373-18-7.mol

Synonyms:

Chemical Property of (3beta,4alpha,8alpha,12xi)-4,15-bis(acetyloxy)-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate

Chemical Property:

• Vapor Pressure: 7.14E-17mmHg at 25°C
• Boiling Point: 599.5°Cat760mmHg
• Flash Point: 197.7°C
• Density: 1.33g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3beta,4alpha,8alpha,12xi)-4,15-bis(acetyloxy)-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate

There total 9 articles about (3beta,4alpha,8alpha,12xi)-4,15-bis(acetyloxy)-3-hydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

C29H42O11 → 3'-Hydroxy T-2 toxin (84474-35-1,97373-18-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In ethanol; for 1h; Heating;

DOI:10.1021/jo00391a063

Reference yield:

T-2 toxin (21259-20-1) → Neosolaniol (36519-25-2) + 3′-hydroxy-T-2 (97373-18-7)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; NADP; magnesium chloride; In aq. buffer; at 37 ℃; for 1.5h; pH=7.4; Reagent/catalyst; Enzymatic reaction;

DOI:10.1371/journal.pone.0106769

Reference yield:

3-Hydroxy-3-methylbutyric acid (625-08-1) → 3'-Hydroxy T-2 toxin (84474-35-1,97373-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-dimethylaminopyridine, dicyclohexylcarbodiimide

2: ammonium hydroxide

With dmap; ammonium hydroxide; dicyclohexyl-carbodiimide;

DOI:10.1080/00021369.1982.10865484

upstream raw materials:

3-Hydroxy-3-methylbutyric acid

4β,15-diacetoxy-3α-(2-tetrahydropyranyloxy)scirpene-8β-ol

T-2 toxin

Refernces

• 1、 Ge, Xiaohu,Wang, Junping,Liu, Jing,Jiang, Jun,Lin, Huina,Wu, Jun,Ouyang, Man,Tang, Xianqing,Zheng, Ming,Liao, Ming,Deng, Yiqun. "The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs". experimental part. p. 71 - 75. Retrieved 2011/02/22.
• 2、 Yoshizawa,Sakamoto,Ayano,Mirocha. "3'-Hydroxy T-2 and 3'-hydroxy HT-2 toxins: New metabolites of T-2 toxin, a trichothecene mycotoxin, in animals". . p. 2613 - 2615. Retrieved 2007/10/02.