2-(2,5-Dimethylphenyl)ethanol

Base Information

• Chemical Name: 2-(2,5-Dimethylphenyl)ethanol
• CAS No.: 6972-51-6
• Molecular Formula: C10H14 O
• Molecular Weight: 150.221
• Hs Code.: 2906299090
• European Community (EC) Number: 654-684-6
• NSC Number: 62109
• DSSTox Substance ID: DTXSID00289590
• Nikkaji Number: J1.394.495D
• Wikidata: Q72471278
• Mol file: 6972-51-6.mol

Synonyms:2-(2,5-dimethylphenyl)ethanol;6972-51-6;2,5-DIMETHYLPHENETHYL ALCOHOL;2-(2,5-dimethylphenyl)ethan-1-ol;NSC62109;SCHEMBL698983;DTXSID00289590;CK1129;MFCD00020610;NSC-62109;AKOS011828380;2-Chloromethylene-malonicaciddiethylester;AS-45833;CS-0061224;FT-0756282;EN300-100638;A866769

Chemical Property of 2-(2,5-Dimethylphenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.00401mmHg at 25°C
• Refractive Index: 1.53-1.532
• Boiling Point: 268℃
• Flash Point: 126℃
• PSA: 20.23000
• Density: 0.986
• LogP: 1.83820
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 150.104465066
• Heavy Atom Count: 11
• Complexity: 111

Purity/Quality:

98% ^*data from raw suppliers

2-(2,5-Dimethylphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)C)CCO

Technology Process of 2-(2,5-Dimethylphenyl)ethanol

There total 14 articles about 2-(2,5-Dimethylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.73%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2,5-dimethylbenzyl bromide (50837-53-1) → 2-(2,5-dimethylphenyl)ethan-1-ol (6972-51-6)

Guidance literature:

2,5-dimethylbenzyl bromide; With iodine; magnesium; In diethyl ether; for 2.16h; Inert atmosphere; Reflux;

formaldehyd; In diethyl ether; at 20 ℃; Temperature; Inert atmosphere;

Reference yield: 94.69%

oxirane (75-21-8,99932-75-9) + 4-bromo-m-xylene (553-94-6) → 2-(2,5-dimethylphenyl)ethan-1-ol (6972-51-6)

Guidance literature:

4-bromo-m-xylene; With iodine; magnesium; In diethyl ether; at 60 ℃; for 1h; Inert atmosphere;

oxirane; In diethyl ether; at 0 ℃; for 3h; Temperature; Inert atmosphere;

Reference yield: 94.41%

oxirane (75-21-8,99932-75-9) + 2-chloro-1,4-dimethyl-benzene (95-72-7) → 2-(2,5-dimethylphenyl)ethan-1-ol (6972-51-6)

Guidance literature:

2-chloro-1,4-dimethyl-benzene; With iodine; magnesium; In tetrahydrofuran; at 60 ℃; for 1h; Inert atmosphere;

oxirane; In tetrahydrofuran; at 5 ℃; for 3h; Inert atmosphere;

upstream raw materials:

oxirane

para-xylene

2,5-dimethylphenylmagnesium bromide

2,5-dimethylphenylacetic acid ethyl ester

Downstream raw materials:

2-(2,5-dimethylphenyl)acetic acid

2-<2,5-Dimethyl-phenyl>-ethylmercaptan

2,2'-Bis-<2,5-dimethyl-phenyl>-diethylsulfid

S-<2-(2,5-Dimethyl-phenyl)-ethyl>-thioglykolsaeureamid

Refernces

• 1、 -. "Method of synthesizing 2,5-dimethyl phenylacetic acid through 2,5-dimethyl benzyl halide". Paragraph 0037-0051. . Retrieved 2019/10/17.
• 2、 Kido, Yoshiyuki,Yonehara, Fumi,Yamaguchi, Masahiko. "Aromatic alkenylation using electrophilic organogallium reagent generated from allenylsilane and GaCl3". . p. 827 - 833. Retrieved 2007/10/03.