2-(Acetamido)thiophene

Base Information

• Chemical Name: 2-(Acetamido)thiophene
• CAS No.: 13053-81-1
• Molecular Formula: C6H7NOS
• Molecular Weight: 141.194
• Hs Code.: 2934999090
• European Community (EC) Number: 235-939-7
• UNII: 8BU665L2ZG
• DSSTox Substance ID: DTXSID90156606
• Nikkaji Number: J150.397I
• Wikidata: Q72508466
• Mol file: 13053-81-1.mol

Synonyms:2-(Acetamido)thiophene;13053-81-1;N-(thiophen-2-yl)acetamide;2-Acetamidothiophene;Acetamide, N-2-thienyl-;N-2-Thienylacetamide;N-(2-Thienyl)acetamide;N-thiophen-2-ylacetamide;Thiophene, 2-acetamido;8BU665L2ZG;EINECS 235-939-7;acetylaminothiophene;N-(2-Thienyl)acetamide #;UNII-8BU665L2ZG;SCHEMBL3091207;DTXSID90156606;HMS1577G16;MFCD00090379;STK367444;AKOS000281660;SDCCGMLS-0064631.P001;NCGC00342170-01;AM20080217;FT-0602651;EN300-80304;Y10605;AB01334500-02;J-507693;F2146-0687;Z1198150448;OK7

Chemical Property of 2-(Acetamido)thiophene

Chemical Property:

• Vapor Pressure: 0.000237mmHg at 25°C
• Refractive Index: 1.611
• Boiling Point: 325 °C at 760 mmHg
• Flash Point: 150.3 °C
• PSA: 57.34000
• Density: 1.26 g/cm³
• LogP: 1.77950
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 141.02483502
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

98%min ^*data from raw suppliers

N-(thiophen-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=CS1

Technology Process of 2-(Acetamido)thiophene

There total 22 articles about 2-(Acetamido)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-acetylthiophene oxime (1956-45-2,92313-45-6,92313-54-7) → 2-acetylaminothiophene (13053-81-1)

Guidance literature:

With tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide; In acetonitrile; for 1h; Molecular sieve; Reflux;

Reference yield: 92.0%

(E)-N-[1-(thiophen-2-yl)ethylidene]hydroxylamine (92313-54-7) → 2-acetylaminothiophene (13053-81-1)

Guidance literature:

With sodium hydroxide; p-toluenesulfonyl chloride; In acetone; at 0 ℃;

Reference yield: 90.0%

thiophen-2-ylamine (616-46-6) + acetic acid (64-19-7,77671-22-8) → 2-acetylaminothiophene (13053-81-1)

Guidance literature:

With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate; at 96 - 100 ℃; for 5h; Temperature; chemoselective reaction;

DOI:10.1016/j.tetlet.2019.151159

upstream raw materials:

2-thienyl lithium

acetamide

2-nitrothiophene

acetic anhydride

Downstream raw materials:

N-(5-nitrothiophen-2-yl)acetamide

N-(3-(4-methoxyphenyl)thiophen-2-yl)acetamide

N-(3-phenylthiophen-2-yl)acetamide

2-Acetamido-3-nitrothiophene

Refernces

• 1、 Stoyanovich, F. M.,Marakatkina, M. A.. "ELECTROPHILIC ACETAMINATION OF THIOPHENE CARBANIONS". . p. 1346. Retrieved 1983.
• 2、 Liu, Yinghui,Wei, Yongjiao,Xie, Lan-Gui. "Dehydrative Beckmann rearrangement and the following cascade reactions". supporting information. . Retrieved 2021/11/16.
• 3、 -. "MODIFIED PROTEINS AND PROTEIN DEGRADERS". Paragraph 00785; 00788; 00789. . Retrieved 2021/12/08.