FLUVASTATIN LACTONE

Base Information

• Chemical Name: FLUVASTATIN LACTONE
• CAS No.: 94061-83-3
• Molecular Formula: C24H24FNO3
• Molecular Weight: 393.458
• Mol file: 94061-83-3.mol

Synonyms:Fluvastatin lactone;

Chemical Property of FLUVASTATIN LACTONE

Chemical Property:

• Melting Point: 55-63°C
• PSA: 51.46000
• LogP: 5.10800
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform, Methanol

Purity/Quality:

99.90% ^*data from raw suppliers

FluvastatinLactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A synthetic HMG-CoA reductase inhibitor.

Technology Process of FLUVASTATIN LACTONE

There total 5 articles about FLUVASTATIN LACTONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

fluvastatin sodium → trans-6-<2-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (93957-56-3,93957-57-4,94061-83-3,141109-99-1)

Guidance literature:

fluvastatin sodium; With hydrogenchloride; In water; ethyl acetate; at 20 ℃; Darkness; Cooling with ice;

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Darkness; Cooling with ice;

Reference yield: 32.0%

fluvastatin sodium (94061-80-0) → Fluvastatin lactone (94061-83-3) + C24H24FNO3

Guidance literature:

In toluene; at 20 ℃; for 168h;

Reference yield:

fluvastatin (155229-75-7) → Fluvastatin lactone (94061-83-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Molecular sieve; Inert atmosphere; Cooling with ice;

upstream raw materials:

fluvastatin sodium

fluvastatin

fluvastatin

Downstream raw materials:

tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

C₂₄H₂₆FNO₃

cis-6-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-3,6-dihydro-2H-pyran-2-acetic acid

7-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2,4,6-heptatrienoic acid

Refernces

• 1、 -. "Multi-substituted indoles lactone dehydration compound and use thereof". . . Retrieved 2017/08/25.
• 2、 -. "COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE". Page/Page column 53. . Retrieved 2008/06/13.