5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE

Base Information

• Chemical Name: 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE
• CAS No.: 71569-15-8
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Hs Code.: 2933499090
• Mol file: 71569-15-8.mol

Synonyms:5,6,7,8-Tetrahydroquinolin-5-ylamine

Chemical Property of 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE

Chemical Property:

• Vapor Pressure: 0.0132mmHg at 25°C
• Boiling Point: 259.1 °C at 760 mmHg
• PKA: 8.57±0.20(Predicted)
• Flash Point: 134.3 °C
• PSA: 38.91000
• Density: 1.081 g/cm³
• LogP: 2.11800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Amino-5,6,7,8-tetrahydroquinoline 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE

There total 4 articles about 5-AMINO-5,6,7,8-TETRAHYDROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(Z/E)-7,8-dihydroquinolin-5(6H)-one O-methyl oxime (1114896-36-4) → 5,6,7,8-tetrahydroquinolin-5-ylamine (71569-15-8,911825-73-5,502612-38-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 16h; under 2585.81 Torr;

Reference yield: 43.0%

5-(N-acetylamino)-5,6,7,8-tetrahydroquinoline (185510-52-5) + N-(5,6,7,8-tetrahydroquinolin-7-yl)acetamide (298182-09-9) → 5,6,7,8-tetrahydroquinolin-5-ylamine (71569-15-8,911825-73-5,502612-38-6) + 5,6,7,8-Tetrahydro-quinolin-7-ylamine (133091-81-3)

Guidance literature:

With hydrogenchloride; In methanol; water; for 48h; Heating / reflux;

Reference yield: 35.0%

5,6,7,8-tetrahydroquinolin-5-one (53400-41-2) → 5,6,7,8-tetrahydroquinolin-5-ylamine (71569-15-8,911825-73-5,502612-38-6)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In methanol; for 48h; Ambient temperature;

DOI:10.1016/S0223-5234(97)89850-9

upstream raw materials:

5,6,7,8-tetrahydroquinolin-5-one

5-(N-acetylamino)-5,6,7,8-tetrahydroquinoline

N-(5,6,7,8-tetrahydroquinolin-7-yl)acetamide

(Z/E)-7,8-dihydroquinolin-5(6H)-one O-methyl oxime

Downstream raw materials:

(S)-5,6,7,8-tetrahydroquinolin-5-ylamine

Refernces

• 1、 -. "ADRENERGIC COMPOUNDS". . . Retrieved 2009/04/25.
• 2、 Dukat, M.,Fiedler, W.,Dumas, D.,Damaj, I.,Martin, B. R.,et al.. "Pyrrolidine-modified and 6-substituted analogs of nicotine: a structure-affinity investigation". . p. 875 - 888. Retrieved 2007/10/03.