3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE
• CAS No.: 63286-28-2
• Molecular Formula: C4H8Cl2N4
• Molecular Weight: 144.564
• Hs Code.: 2933990090
• Mol file: 63286-28-2.mol

Synonyms:2(1H)-Pyrazinone,3-chloro-, hydrazone (9CI);2-Chloro-3-hydrazinopyrazine;2-Hydrazino-3-chloropyrazine;NSC 272203;2-chloro-3-hydrazinopyrazine;

Chemical Property of 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 154-159°C
• Boiling Point: 299.5 °C at 760 mmHg
• PKA: 1.27±0.20(Predicted)
• Flash Point: 134.9 °C
• PSA: 63.83000
• Density: 1.53 g/cm³
• LogP: 1.18890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.5% ^*data from raw suppliers

3-Chloro-2-Hydrazino-1,2-Dihydropyrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE

There total 3 articles about 3-CHLORO-2-HYDRAZINO-1,2-DIHYDROPYRAZINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-dichloropyrazine (4858-85-9) → 2-chloro-3-hydrazinopyrazine (63286-28-2)

Guidance literature:

2,3-dichloropyrazine; With hydrazine hydrate; In ethanol; for 6h; Reflux;

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1039/c9cc03765a

Reference yield: 73.0%

2-chloropyrimidin-4-amine (7461-50-9) → 2-chloro-3-hydrazinopyrazine (63286-28-2)

Guidance literature:

With hydrazine; In ethanol; water;

Reference yield:

→ 2-chloro-3-hydrazinopyrazine (63286-28-2)

Guidance literature:

2,3-Dichlor-pyrazin, N2H4*H2O;

DOI:10.1021/jo01321a002

upstream raw materials:

2,3-dichloropyrazine

2-chloropyrimidin-4-amine

Downstream raw materials:

8-chloro-[1,2,4]triazolo[4,3-a]pyrazine

8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine

8-chloro-3-phenyl-[1.2.4]triazolo[4,3-a]pyrazine

8-chloro-3-ethyl[1,2,4]triazolo[4,3-a]piperazine

Refernces

• 1、 Liu, Xiaobo,Sun, Xin,Xiong, Hehua,Xu, Shan,Yang, Zunhua,Zhang, Binliang,Zhang, Qian,Zheng, Pengwu,Zhu, Wufu. "Discovery of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing a 4-oxo-pyridazinone moiety as potential c-Met kinase inhibitors". . p. 9053 - 9063. Retrieved 2020/06/08.
• 2、 -. "PYRIDAZINIUM COMPOUNDS FOR USE IN CONTROLLING UNWANTED PLANT GROWTH". Page/Page column 57. . Retrieved 2020/08/22.