2,5-Dimethylpyridine

Base Information

• Chemical Name: 2,5-Dimethylpyridine
• CAS No.: 589-93-5
• Molecular Formula: C7H9 N
• Molecular Weight: 107.155
• Hs Code.: 2933399090
• European Community (EC) Number: 209-666-9
• NSC Number: 5089
• UNII: 6L09RM76RH
• DSSTox Substance ID: DTXSID0060436
• Nikkaji Number: J6.752K
• Wikidata: Q23636061
• Mol file: 589-93-5.mol

Synonyms:2,5-DIMETHYLPYRIDINE;2,5-Lutidine;589-93-5;Pyridine, 2,5-dimethyl-;2,5-dimethyl-pyridine;NSC 5089;EINECS 209-666-9;UNII-6L09RM76RH;6L09RM76RH;NSC-5089;MFCD00006343;NSC5089;5-methyl-2-methylpyridine;2,5-Lutidine, 95%;SCHEMBL31030;WLN: T6NJ B1 E1;DTXSID0060436;AKOS005258301;LS-88369;FT-0610498;L0065;EN300-61695;I10249;J-507375;Q23636061

Chemical Property of 2,5-Dimethylpyridine

Chemical Property:

• Appearance/Colour: Colorless liquid.
• Vapor Pressure: 2.4 mm Hg ( 20 °C)
• Melting Point: -15 ºC
• Refractive Index: n20/D 1.499(lit.)
• Boiling Point: 157 ºC
• PKA: 6.4(at 25℃)
• Flash Point: 48 ºC
• PSA: 12.89000
• Density: 0.926
• LogP: 1.69840
• Sensitive.: Hygroscopic
• Water Solubility.: 77g/L(23 oC)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 107.073499291
• Heavy Atom Count: 8
• Complexity: 70.8

Purity/Quality:

99% ^*data from raw suppliers

2,5-Lutidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,F,Xi
• Statements: 10-20/21/22-36/37/38
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: CC1=CN=C(C=C1)C
• Uses: 2,5-Lutidine was used to displace CO from the haem iron.

Technology Process of 2,5-Dimethylpyridine

There total 41 articles about 2,5-Dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,5-dimethylpyridine N-oxide (4986-05-4) → 2,5-dimethylpyridine (589-93-5)

Guidance literature:

With titanium tetrachloride; tin(ll) chloride; In benzene; for 0.5h; Ambient temperature;

Reference yield: 84.0%

propan-1-ol (71-23-8) + 3-Methylpyridine (108-99-6) → 2,5-dimethylpyridine (589-93-5)

Guidance literature:

With Raney nickel; at 180 ℃; for 0.5h; Concentration; regioselective reaction; Flow reactor; Green chemistry;

DOI:10.3390/molecules200915797

Reference yield: 84.0%

3-Methylpyridine (108-99-6) + octanol (111-87-5) → 2,5-dimethylpyridine (589-93-5)

Guidance literature:

With Ra-Ni; for 438h; regioselective reaction; Reflux;

DOI:10.1080/00397910802213745

upstream raw materials:

6-methyl-3-pyridinemethanol

5-methyl-2-pyridineacetonitrile

2,4-dichloro-3,6-dimethylpyridine

methanol

Downstream raw materials:

1-benzyl-1,4-dihydronicotinamide radical

2,5-dimethylpyridine conjugate acid

2-ethyl-5-methylpyridine

5-methylpicolinaldehyde

Refernces

• 1、 Nagaki, Aiichiro,Yamada, Daisuke,Yamada, Shigeyuki,Doi, Masatomo,Ichinari, Daisuke,Tomida, Yutaka,Takabayashi, Naofumi,Yoshida, Jun-Ichi. "Generation and reactions of pyridyllithiums via Br/li exchange reactions using continuous flow microreactor systems". . p. 199 - 207. Retrieved 2013/03/28.
• 2、 Harrod,Shu,Woo,Samuel. "Titanocene(III) catalyzed homogeneous hydrosilation-hydrogenation of pyridines". . p. 1075 - 1085. Retrieved 2007/10/03.