2-Ethyl-5-methylpyridine

Base Information

• Chemical Name: 2-Ethyl-5-methylpyridine
• CAS No.: 18113-81-0
• Molecular Formula: C8H11N
• Molecular Weight: 121.182
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20334051
• Nikkaji Number: J28.090I
• Wikidata: Q82099685
• Metabolomics Workbench ID: 48786
• Mol file: 18113-81-0.mol

Synonyms:2-Ethyl-5-methylpyridine;18113-81-0;Pyridine, 2-ethyl-5-methyl-;5-Methyl-2-ethyl pyridine;6-Ethyl-3-picoline;6-Ethyl-3-methylpyridine;SCHEMBL469189;DTXSID20334051;CHEBI:179424;SB54346;BS-49493;E78001;EN300-7613348

Chemical Property of 2-Ethyl-5-methylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 1.95240
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 121.089149355
• Heavy Atom Count: 9
• Complexity: 80.6

Purity/Quality:

99%, ^*data from raw suppliers

2-Ethyl-5-methylpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=NC=C(C=C1)C
• Use Description: 2-ethyl-5-methylpyridine is a chemical compound with diverse applications across different fields. In the pharmaceutical industry, it serves as a key building block for the synthesis of various drugs and pharmaceutical intermediates, contributing to the development of medications for a wide range of medical conditions. Its role is pivotal in the creation of complex organic molecules with therapeutic properties. Additionally, in the field of agriculture and agrochemicals, this compound can be used in the formulation of pesticides and herbicides, aiding in crop protection and weed control. Furthermore, in academic research and organic chemistry, it serves as a reference compound for the study of pyridine derivatives and their reactions, contributing to our understanding of chemical processes and compound synthesis. Its multifaceted utility underscores its significance in advancing pharmaceuticals, agriculture, and chemical research, where it plays a crucial role in drug discovery, crop management, and scientific investigation.

Technology Process of 2-Ethyl-5-methylpyridine

There total 17 articles about 2-Ethyl-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.1%

3-Methylpyridine (108-99-6) + ethanol (64-17-5) → 2-ethyl-5-methylpyridine (18113-81-0)

Guidance literature:

ammonium chloride; at 335 ℃; for 5h; Product distribution; variation of reaction temperature, and catalysts;

Reference yield:

6-ethyl-2,4-dichloro-3-methyl-pyridine → 2-ethyl-5-methylpyridine (18113-81-0)

Guidance literature:

With methanol; sodium methylate; nickel; Hydrogenation;

DOI:10.1002/hlca.19420250620

Reference yield:

2,5-dimethylpyridine (589-93-5) → 2-ethyl-5-methylpyridine (18113-81-0)

Guidance literature:

With ammonia; sodium amide; anschliessend Behandeln mit Methyljodid;

DOI:10.1021/ja01564a037

upstream raw materials:

2,5-dimethylpyridine

picoline

ethanol

3-Methylpyridine

Downstream raw materials:

2-Ethyl-5-methyl-pyridin-1-oxid

1-(5-methyl-pyridin-2-yl)-ethanone

(+/-)-deoxynupharidine

(+/-)-1-epideoxynupharidine

Refernces

• 1、 Petiot, Pauline,Gagnon, Alexandre. "Palladium-catalyzed cross-coupling reaction of trialkylbismuthines with 2-haloazines and diazines". . p. 1615 - 1624. Retrieved 2016/10/12.
• 2、 Kashiwagi, Hiroshi,Enomoto, Saburo. "Catalytic Reactions of Pyridines. V. Alkylation of α-, β-, and γ-Picolines with Alcohols catalyzed by Ammonium Halides". . p. 2213 - 2218. Retrieved 2007/10/02.