Sodium deoxycholate

Base Information

• Chemical Name: Sodium deoxycholate
• CAS No.: 302-95-4
• Molecular Formula: C24H39NaO4
• Molecular Weight: 414.561
• Hs Code.: 29181930
• Mol file: 302-95-4.mol

Synonyms:5b-Cholan-24-oic acid, 3a,12a-dihydroxy-, monosodium salt (8CI);Deoxycholic acidmonosodium salt;Deoxycholic acid sodium salt;Desoxycholate sodium;Desoxycholic acid sodium salt;NSC 681065;Sodium 3a,12a-dihydroxy-5b-cholanate;Sodium 7-deoxycholate;Sodium deoxycholate;Sodium desoxycholate;Sodium Deoxycholic acid;

Chemical Property of Sodium deoxycholate

Chemical Property:

• Appearance/Colour: white to cream crystalline powder
• Vapor Pressure: 0Pa at 20℃
• Melting Point: 357-365 °C
• Boiling Point: 547.148 °C at 760 mmHg
• Flash Point: 298.768 °C
• PSA: 80.59000
• Density: 1.129 g/cm³
• LogP: 3.14320
• Storage Temp.: Store at RT.
• Solubility.: water: soluble1 gm in 10 ml, clear, colorless to very faintly ye
• Water Solubility.: 330 g/L (15 ºC)

Purity/Quality:

98%, ^*data from raw suppliers

Sodium deoxycholate Suitable for manufacturing of diagnostic kits and reagents ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Sodium deoxycholate is used as a component in cell lysis buffers. Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins. Sodium deoxycholate is used as a choleretic and an anionic detergent. It is useful for the extraction of membrane receptors, plasma membrane proteins, nuclei isolation and solubilizes fats as well as membrane components. It acts as an intermediate for the production of corticosteroids and microbiological diagnostic media. In addition, it acts as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Technology Process of Sodium deoxycholate

There total 2 articles about Sodium deoxycholate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

insulin → sodium cholate (302-95-4)

Guidance literature:

In tetrahydrofuran;

Reference yield:

Deoxycholic acid (83-44-3) → sodium cholate (302-95-4)

Guidance literature:

With disodium hydrogenphosphate; sodium hydroxide; pH=8.3;

Reference yield: 84.6%

sodium cholate (302-95-4) + triphenyltin chloride (639-58-7) → (R)-triphenylstannyl 4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

Guidance literature:

In toluene; Inert atmosphere; Reflux;

DOI:10.1080/00958972.2014.908187

upstream raw materials:

Deoxycholic acid

Downstream raw materials:

12α-hydroxypregn-4-en-3-one-20-carboxylic acid methyl ester

methyl 12α-hydroxy-3-oxo-5β-cholan-24-oate

(S)-2-((8R,9S,10R,12S,13S,14S,17R)-12-Hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-propionic acid methyl ester

methyl 12α-hydroxy-3-ketochola-1,4-dienoate

Refernces

• 1、 -. "INSULIN-LIPID COMPLEX, PREPARATION METHOD THEREFOR, AND PREPARATION THEREOF". Page/Page column. . Retrieved 2013/06/05.