methyl 12α-hydroxy-3-ketochola-1,4-dienoate

Base Information

• Chemical Name: methyl 12α-hydroxy-3-ketochola-1,4-dienoate
• CAS No.: 106759-10-8
• Molecular Formula: C₂₅H₃₆O₄
• Molecular Weight: 400.558
• Mol file: 106759-10-8.mol

Synonyms:methyl 12α-hydroxy-3-ketochola-1,4-dienoate

Chemical Property of methyl 12α-hydroxy-3-ketochola-1,4-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 12α-hydroxy-3-ketochola-1,4-dienoate

There total 1 articles about methyl 12α-hydroxy-3-ketochola-1,4-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + sodium cholate (302-95-4) → 12α-hydroxypregn-4-en-3-one-20-carboxylic acid methyl ester (80374-03-4) + methyl 12α-hydroxy-3-oxo-5β-cholan-24-oate (10538-58-6) + (S)-2-((8R,9S,10R,12S,13S,14S,17R)-12-Hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-propionic acid methyl ester (86496-41-5) + methyl 12α-hydroxy-3-ketochola-1,4-dienoate (106759-10-8)

Guidance literature:

With boron trifluoride; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) water, 28 deg C, 16 h, Pseudomonas NCIB 10590, K₂HPO₄, KHPO₄, KNO₃, FeSO₄*7H₂O, ZnSO₄*7H₂O, MnSO₄*4H₂O, MgSO₄*7H₂O, pH=7, aeration;

DOI:10.1016/S0040-4020(01)88910-9

Reference yield: 26.0%

methyl 12α-hydroxy-3-ketochola-1,4-dienoate (106759-10-8) → methyl 12α-hydroxy-3-oxo-5β-cholan-24-oate (10538-58-6) + methyl 3-oxo-12α-hydroxy-5α-cholan-24-oate

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 735.5 Torr; Ambient temperature;

DOI:10.1016/0039-128X(89)90022-6

Reference yield:

methyl 12α-hydroxy-3-ketochola-1,4-dienoate (106759-10-8) → 12α-hydroxychol-4-en-3-one-24-coic acid methyl ester (19684-72-1)

Guidance literature:

With hydrogen; Wilkinson's catalyst; In benzene; Yield given;

DOI:10.1016/0039-128X(89)90022-6

upstream raw materials:

methanol

sodium cholate

Downstream raw materials:

12α-hydroxychol-4-en-3-one-24-coic acid methyl ester

methyl 12α-hydroxy-3-oxo-5β-cholan-24-oate

Refernces