1-Palmitoylphosphatidylcholine

Base Information

• Chemical Name: 1-Palmitoylphosphatidylcholine
• CAS No.: 17364-18-0
• Molecular Formula: C24H50 N O7 P
• Molecular Weight: 495.637
• Hs Code.: 2923900090
• European Community (EC) Number: 241-396-7
• DSSTox Substance ID: DTXSID901306323
• Wikidata: Q92466416
• Metabolomics Workbench ID: 75121
• Mol file: 17364-18-0.mol

Synonyms:1-O-hexadecylpropanediol 3-phosphorylcholine;1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine;1-palmitoyl-sn-glycerol-3-phosphorylcholine;1-palmitoylglycerol-3-phosphorylcholine;1-palmitoyllysophosphatidylcholine;hydroxide inner salt(+-)-isomer of We 201;hydroxide inner salt(R)-isomer of We 201;hydroxide inner salt(S)-isomer of We 201;LYSO-PC;palmitoyl lysophosphatidylcholine;We 201;We-201

Chemical Property of 1-Palmitoylphosphatidylcholine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 114.93000
• Density: g/cm³
• LogP: 5.64980
• Storage Temp.: −20°C
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 24
• Exact Mass: 495.33248993
• Heavy Atom Count: 33
• Complexity: 517

Purity/Quality:

98%Min ^*data from raw suppliers

1-PALMITOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)O

Technology Process of 1-Palmitoylphosphatidylcholine

There total 60 articles about 1-Palmitoylphosphatidylcholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

L-dipalmitoylphosphatidylcholine (63-89-8) → 1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5)

Guidance literature:

With sodium docusate; phospholipase A₂; In aq. buffer; at 40 ℃; for 0.5h; pH=8.5;

DOI:10.1371/journal.pone.0157278

Reference yield: 98.0%

n-hexadecanoyl chloride (112-67-4) → 1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5)

Guidance literature:

L-glycero-3-phosphorylcholine; With di(n-butyl)tin oxide; In methanol; for 1.5h; Heating / reflux;

n-hexadecanoyl chloride; With triethylamine; In WA; at 25 ℃; Product distribution / selectivity;

Reference yield: 98.0%

1-palmitoyl-2-(tetrahydropyran-2-yl)-sn-3-glycerophosphocholine (605680-01-1) → 1-palmitoyl-sn-glycero-3-phosphocholine (17364-16-8,17364-17-9,17364-18-0,14863-27-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/jo062352f

upstream raw materials:

hexadecanoic acid, glycidyl ester

choline phosphate

1-palmitoyl-2-benzylglycerophosphocholine

L-dipalmitoylphosphatidylcholine

Downstream raw materials:

1-palmitoyl-sn-glycero-3-phosphocholine

PGPC

2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine

lecithin

Refernces

• 1、 -. "A high-purity dissolved blood phosphatidyl choline and its preparation method (by machine translation)". Paragraph 0065-0066. . Retrieved 2019/01/15.
• 2、 K?obucki, Marek,Grudniewska, Aleksandra,Smuga, Damian A.,Smuga, Ma?gorzata,Jarosz, Joanna,Wietrzyk, Joanna,Maciejewska, Gabriela,Wawrzeńczyk, Czes?aw. "Syntheses and antiproliferative activities of novel phosphatidylcholines containing dehydroepiandrosterone moieties". . p. 109 - 118. Retrieved 2017/01/12.