Glycidyl Palmitate

Base Information

• Chemical Name: Glycidyl Palmitate
• CAS No.: 7501-44-2
• Molecular Formula: C19H36 O3
• Molecular Weight: 312.493
• Mol file: 7501-44-2.mol

Synonyms:Hexadecanoicacid, oxiranylmethyl ester (9CI); Palmitic acid, 2,3-epoxypropyl ester (8CI); (?à)-Glycidyl palmitate; Glycidylhexadecanoate; Glycidyl palmitate; NSC 406558; Palmitic acid glycidyl ester

Chemical Property of Glycidyl Palmitate

Chemical Property:

• Vapor Pressure: 1.73E-06mmHg at 25°C
• Melting Point: 39-41?C
• Boiling Point: 396.3°C at 760 mmHg
• Flash Point: 152.4°C
• PSA: 38.83000
• Density: 0.938g/cm³
• LogP: 5.40970
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Sparingly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Glycidyl Palmitate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Glycidyl Palmitate is used for preparation of lysophosphatidic acids which inhibit apoptosis.

Technology Process of Glycidyl Palmitate

There total 7 articles about Glycidyl Palmitate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium palmitate (408-35-5) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → hexadecanoic acid, glycidyl ester (7501-44-2)

Guidance literature:

With tetraethylammonium iodide; for 0.416667h; Heating;

Reference yield: 79.0%

oxiranyl-methanol (556-52-5) + 1-hexadecylcarboxylic acid (57-10-3) → hexadecanoic acid, glycidyl ester (7501-44-2)

Guidance literature:

1-hexadecylcarboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.0833333h; Inert atmosphere;

oxiranyl-methanol; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling;

DOI:10.1007/s11746-011-1802-3

Reference yield: 70.0%

oxiranyl-methanol (556-52-5) + n-hexadecanoyl chloride (112-67-4) → hexadecanoic acid, glycidyl ester (7501-44-2) + 1-palmitoyl-3-chloro-1,2-propanediol (30557-04-1)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1007/s11746-011-1802-3

upstream raw materials:

oxiranyl-methanol

n-hexadecanoyl chloride

sodium palmitate

epichlorohydrin

Downstream raw materials:

L-dipalmitoylphosphatidylcholine

1-palmitoyl-2-linoleoyl-3-hydroxyl-rac-glycerol

1-palmitoyl-sn-glycero-3-phosphocholine

dimethyl (3-hexadecanoyloxy-2-hydroxypropyl) sulfonium dibenzoyltartrate

Refernces

• 1、 -. "GLYCEROL DERIVATIVE, PREPARATION METHOD THEREFOR, AND IMMUNOMODULATOR COMPRISING SAME AS EFFECTIVE INGREDIENT". Paragraph 0072-0073. . Retrieved 2021/07/02.
• 2、 Kaze, Naoki,Sato, Hirofumi,Yamamoto, Hiroshi,Watanabe, Yomi. "Bidirectional conversion between 3-monochloro-1,2-propanediol and glycidol in course of the procedure of DGF standard methods". experimental part. p. 1143 - 1151. Retrieved 2011/11/12.