Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[(acetyloxy)methyl]-7-[[(2S)-hydroxyphenylacetyl]amino]-8-oxo-,
(6R,7R)-
There total 2 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[(acetyloxy)methyl]-7-[[(2S)-hydroxyphenylacetyl]amino]-8-oxo-,
(6R,7R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: thionyl chloride, dimethylformamide / Heating
2: 2.) KHCO3 / 1.) acetone, water, room temperature, 2.) methanol, room temperature
With
thionyl chloride; potassium hydrogencarbonate; N,N-dimethyl-formamide;
- Guidance literature:
-
With
potassium hydrogencarbonate;
Multistep reaction;
1.) acetone, water, room temperature, 2.) methanol, room temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: KHCO3 / dimethylformamide / 5 h / Ambient temperature
2: 77 percent / lithium methoxide, t-butyl hypochlorite, glacial acetic acid / tetrahydrofuran / 1.) -72 deg C, 20 min, 2.) -70 deg C, 30 min, 3.) -70 deg C --> room temperature
3: 90 percent / H2 / Pd/C / ethyl acetate; methanol / 1.5 h / Ambient temperature
With
tert-butylhypochlorite; lithium methanolate; hydrogen; potassium hydrogencarbonate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;