4-HYDROXY NIMESULIDE

Base Information

• Chemical Name: 4-HYDROXY NIMESULIDE
• CAS No.: 109032-22-6
• Molecular Formula: C13H12 N2 O6 S
• Molecular Weight: 324.314
• Hs Code.: 2935009090
• Mol file: 109032-22-6.mol

Synonyms:4-Hydroxynimesulide;4'-Hydroxynimesulide

Chemical Property of 4-HYDROXY NIMESULIDE

Chemical Property:

• Vapor Pressure: 1.72E-10mmHg at 25°C
• Boiling Point: 496.7°Cat760mmHg
• PKA: 6.16±0.10(Predicted)
• Flash Point: 254.2°C
• PSA: 129.83000
• Density: 1.538g/cm³
• LogP: 4.14120

Purity/Quality:

98%min ^*data from raw suppliers

4’-HydroxyNimesulide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A main metabolite of Nimesulide The main metabolite of Nimesulide (N477500).

Technology Process of 4-HYDROXY NIMESULIDE

There total 8 articles about 4-HYDROXY NIMESULIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-(4-methoxyphenoxy)-4-nitro phenyl)methanesulfonamide → 4-Hydroxy-Nimesulide (109032-22-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 5 - 20 ℃; for 2h;

DOI:10.1248/bpb.b21-00608

Reference yield:

nimesulide (51803-78-2) → N-(4-amino-2-phenoxy phenyl) methanesulfonamide (51765-60-7) + 4-Hydroxy-Nimesulide (109032-22-6)

Guidance literature:

With sodium tetrahydroborate; oxygen; Cl₈-5,10,15,20-tetraphenylporphyrinatoiron(III) chloride; at 25 ℃; for 2h;

DOI:10.1248/cpb.50.1421

Reference yield:

N-(2-(4-methoxyphenoxy)-4-nitrophenyl)methanesulfonamide (51765-76-5) → 4-Hydroxy-Nimesulide (109032-22-6)

Guidance literature:

With hydrogen bromide; In water; acetic acid; for 5h; Heating;

upstream raw materials:

nimesulide

N-(2-(4-methoxyphenoxy)-4-nitrophenyl)methanesulfonamide

N-(2-(4-methoxyphenoxy)phenyl)methanesulfonamide

2-(4-methoxyphenoxy)nitrobenzene

Refernces

• 1、 Singh, Parmjeet,Singh, Amarjit,Sharma. "A total synthesis of 4-hydroxynimesulide". . p. 1263 - 1264. Retrieved 2007/10/03.