2,3-Dimethoxy-α-methylphenethyl alcohol

Base Information

• Chemical Name: 2,3-Dimethoxy-α-methylphenethyl alcohol
• CAS No.: 33414-37-8
• Molecular Formula: C11H16O3
• Molecular Weight: 196.2429
• Hs Code.: 2909499000
• Mol file: 33414-37-8.mol

Synonyms:

Chemical Property of 2,3-Dimethoxy-α-methylphenethyl alcohol

Chemical Property:

• Vapor Pressure: 0.00132mmHg at 25°C
• Boiling Point: 285.3°Cat760mmHg
• Flash Point: 126.4°C
• PSA: 38.69000
• Density: 1.062g/cm³
• LogP: 1.62710

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dimethoxy-α-methylphenethyl alcohol

There total 2 articles about 2,3-Dimethoxy-α-methylphenethyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1,2-dimethoxybenzene (91-16-7) + methyloxirane (75-56-9,16033-71-9) → 1-(2',3'-dimethoxyphenyl)propan-2-ol (33414-37-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 3 h, 2.) room temperature, 8 h;

DOI:10.1021/jo970570q

Reference yield:

1-(2,3-dimethoxyphenyl)propan-2-one (3081-67-2) → 1-(2',3'-dimethoxyphenyl)propan-2-ol (33414-37-8)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1002/jps.2600600533

Reference yield: 60.0%

1-(2',3'-dimethoxyphenyl)propan-2-ol (33414-37-8) → 1-(2,3-dimethoxyphenyl)propan-2-one (3081-67-2)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 1h;

DOI:10.1021/jo970570q

upstream raw materials:

1-(2,3-dimethoxyphenyl)propan-2-one

1,2-dimethoxybenzene

methyloxirane

Downstream raw materials:

1-(2,3-dimethoxyphenyl)propan-2-one

4-(2',3'-dimethoxyphenyl)-4-methyl-3-vinylcyclohex-2-enone

3-(2',3'-dimethoxyphenyl)butan-2-one

6-(2',3'-dimethoxyphenyl)-3-methoxy-6-methylcyclohex-2-enone

Refernces

• 1、 Barfknecht,Smith,Nichols,Leseney,Long,Engelbrecht. "Chemistry and pharmacological evaluation of 1-phenyl-2-propanols and 1-phenyl-2-propanones.". . p. 799 - 801. Retrieved 2007/10/05.