Propylene glycol dilaurate

Base Information

• Chemical Name: Propylene glycol dilaurate
• CAS No.: 22788-19-8
• Molecular Formula: C27H52O4
• Molecular Weight: 440.707
• Hs Code.: 2915900000
• European Community (EC) Number: 245-217-3
• UNII: RMY7XGC3LV
• DSSTox Substance ID: DTXSID20945469
• Nikkaji Number: J45.504K
• Wikidata: Q27288198
• Mol file: 22788-19-8.mol

Synonyms:Propylene glycol dilaurate;22788-19-8;2-dodecanoyloxypropyl dodecanoate;Propylene dilaurate;RMY7XGC3LV;UNII-RMY7XGC3LV;Dodecanoic acid, 1-methyl-1,2-ethanediyl ester;propane-1,2-diyl didodecanoate;Propylene glycol dilaurate [NF];EINECS 245-217-3;Dodecanoic acid,1-methyl-1,2-ethanediyl ester;Propylene glycol dilaurate (NF);1,2-Propyleneglycol dilaurate;1,2-propylene glycol dilaurate;SCHEMBL16584788;DTXSID20945469;propylene glycol dilaurate, AldrichCPR;HY-W127419;PROPYLENE GLYCOL DILAURATE [INCI];PROPYLENE GLYCOL DILAURATE [MART.];PROPYLENE GLYCOL DILAURATE [USP-RS];CS-0185653;D08979;J-014855;Q27288198

Chemical Property of Propylene glycol dilaurate

Chemical Property:

• Vapor Pressure: 2.61E-10mmHg at 25°C
• Refractive Index: 1.454
• Boiling Point: 504.7 °C at 760 mmHg
• Flash Point: 235.8 °C
• PSA: 52.60000
• Density: 0.915 g/cm³
• LogP: 8.30310
• Solubility.: Practically insoluble in water, very soluble in alcohol, in methanol and in methylene chloride.
• XLogP3: 10.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 25
• Exact Mass: 440.38656014
• Heavy Atom Count: 31
• Complexity: 408

Purity/Quality:

98%Min ^*data from raw suppliers

Propylene glycol dilaurate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCCCC
• Uses: Propylene Glycol Dilaurate is used in the synthesis of lipid-based drug delivery systems. Surfactant. Excipient.

Technology Process of Propylene glycol dilaurate

There total 4 articles about Propylene glycol dilaurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.4%

lauric acid (143-07-7) + propylene glycol (57-55-6,63625-56-9) → propylene glycol monolaurate (22788-19-8)

Guidance literature:

With phosphate buffer; lipase from Humicola lanuginosa No_. 3; In water; at 45 ℃; for 18h;

Reference yield:

propylene glycol (57-55-6,63625-56-9) + lauric anhydride (645-66-9) → propylene glycol monolaurate (22788-19-8) + propylene glycol monolaurate (142-55-2)

Guidance literature:

In toluene; at 30 ℃; for 6h; Product distribution; Pseudomonas lipase; other fatty acids, acid anhydrides, fatty acids ethyl esters and triglycerides; var. solvents, var. temperature, var. reaction time, effect of water content and pH memory (for lipase);

DOI:10.1007/BF02541427

Reference yield:

lauric acid (143-07-7) + methyloxirane (75-56-9,16033-71-9) → propylene glycol monolaurate (22788-19-8)

Guidance literature:

With potassium hydroxide; at 160 ℃;

DOI:10.1007/BF02540263

upstream raw materials:

n-dodecanoyl chloride

propylene glycol

lauric acid

lauric anhydride

Downstream raw materials:

lauric acid

1,2-bis-sulfooxy-propane

Refernces

• 1、 Omar, Ibrahim Che,Nishio, Naomichi,Nagai, Shiro. "Fat Hydrolysis and Esterification by a Lipase from Humicola lanuginosa". . p. 2153 - 2160. Retrieved 2007/10/02.