Ttnpb

Base Information Edit

Chemical Name:Ttnpb
CAS No.:71441-28-6
Molecular Formula:C24H28 O2
Molecular Weight:348.485
Hs Code.:
European Community (EC) Number:622-084-3
UNII:673M8C29UR
DSSTox Substance ID:DTXSID6040743
Nikkaji Number:J325.995A
Wikidata:Q27089031
Pharos Ligand ID:UZ3U2U7RWWXB
Metabolomics Workbench ID:147428
ChEMBL ID:CHEMBL275311
Mol file:71441-28-6.mol

Synonyms:4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid;AGN 191183;AGN-191183;arotinoid Ro-137410;Ro 13-7410;TTNPB

Suppliers and Price of Ttnpb

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
TTNPB
10mg
$ 423.00

TRC
TTNPB
5mg
$ 80.00

Tocris
TTNPB ≥98%(HPLC)
50
$ 710.00

Tocris
TTNPB ≥98%(HPLC)
10
$ 170.00

TCI Chemical
TTNPB
5MG
$ 119.00

TCI Chemical
TTNPB
25MG
$ 356.00

Sigma-Aldrich
TTNPB
10mg
$ 400.52

Sigma-Aldrich
TTNPB
10mg
$ 216.00

Medical Isotopes, Inc.
TTNPB
100 mg
$ 1175.00

DC Chemicals
TTNPB >98%
250 mg
$ 900.00

Total 32 raw suppliers

Chemical Property of Ttnpb Edit

Chemical Property:

Appearance/Colour:White Solid
Vapor Pressure:2.72E-10mmHg at 25°C
Melting Point:242 °C
Refractive Index:1.4480 (estimate)
Boiling Point:486.8 °C at 760 mmHg
PKA:4.28±0.10(Predicted)
Flash Point:228.6 °C
PSA：37.30000
Density:1.06 g/cm³
LogP:6.29430
Storage Temp.:−20°C
Solubility.:chloroform/methanol: soluble9.80 - 10.20 mg/mL, clear, colorless
XLogP3:7.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:348.208930132
Heavy Atom Count:26
Complexity:549

Purity/Quality:

98%,99%, ^*data from raw suppliers

TTNPB ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 60-61-36/37/38
Safety Statements: 53-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
Isomeric SMILES:C/C(=C\C1=CC=C(C=C1)C(=O)O)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
Description TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Uses TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (RAR; EC50 = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively; Beard et al.; Wong et al.). TTNPB has been used for transcriptional assays in 293T cells. It has also been used as a RAR-agonist in cultured human cord blood CD34+CD38-lin- cells. It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 μM). TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation. TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors.

Technology Process of Ttnpb

There total 27 articles about Ttnpb which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%