4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide

Base Information

• Chemical Name: 4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide
• CAS No.: 15970-86-2
• Molecular Formula: C₁₀H₁₂N₄O₅
• Molecular Weight: 268.229
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40166715
• ChEMBL ID: CHEMBL1630890
• Mol file: 15970-86-2.mol

Synonyms:15970-86-2;4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide;BRN 1019612;N-[(E)-(5-nitrofuran-2-yl)methylideneamino]morpholine-4-carboxamide;N/'-[(5-Nitro-2-furyl)methylene]morpholine-4-carbohydrazide;CHEMBL1630890;DTXSID40166715;NVAUCWNDTOEUTI-YRNVUSSQSA-N;LS-92577;N-[(E)-(5-nitro-2-furyl)methyleneamino]morpholine-4-carboxamide;4-morpholinecarboxylic acid, [(1E)-(5-nitro-2-furanyl)methylene]hydrazide

Chemical Property of 4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 116.38000
• Density: 1.55g/cm³
• LogP: 1.22900
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 268.08076950
• Heavy Atom Count: 19
• Complexity: 363

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)NN=CC2=CC=C(O2)[N+](=O)[O-]
• Isomeric SMILES: C1COCCN1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-]

Technology Process of 4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide

There total 3 articles about 4-Morpholinecarboxylic acid, (5-nitrofurfurylidine)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

morpholine-4-carbohydrazide (29053-23-4) + 5-nitro-2-furfuraldehyde diacetate (92-55-7) → morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide (15970-86-2)

Guidance literature:

With sulfuric acid; water; Ambient temperature;

DOI:10.1016/S0014-827X(97)00011-6

Reference yield:

morpholine-4-carbohydrazide (29053-23-4) + 5-nitrofurane-2-carboxaldehyde (698-63-5) → morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide (15970-86-2)

Guidance literature:

DOI:10.1021/jm00316a006

Reference yield:

4-(phenyloxycarbonyl)morpholine (69630-20-2) → morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide (15970-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / N₂H₄*H₂O / 12 h / 80 - 90 °C

2: 60 percent / H₂SO₄, H₂O / Ambient temperature

With sulfuric acid; water; hydrazine hydrate;

DOI:10.1016/S0014-827X(97)00011-6

upstream raw materials:

morpholine-4-carbohydrazide

5-nitrofurane-2-carboxaldehyde

5-nitro-2-furfuraldehyde diacetate

4-(phenyloxycarbonyl)morpholine

Refernces