Morpholine-4-carbohydrazide

Base Information

• Chemical Name: Morpholine-4-carbohydrazide
• CAS No.: 29053-23-4
• Molecular Formula: C₅H₁₁N₃O₂
• Molecular Weight: 145.161
• Hs Code.: 2934999090
• European Community (EC) Number: 872-035-7
• DSSTox Substance ID: DTXSID80380615
• Nikkaji Number: J1.865.009F
• Wikidata: Q82170938
• Mol file: 29053-23-4.mol

Synonyms:morpholine-4-carbohydrazide;29053-23-4;morpholine-hydrazide;SCHEMBL5117284;DTXSID80380615;XOGXFOXHAJFGKI-UHFFFAOYSA-N;4-Morpholinecarboxylicacid,hydrazide;MFCD01570142;4-Morpholinecarboxylic acid, hydrazide;AKOS009158586;s11963;BS-22222;CS-0206791;FT-0628994;EN300-59486

Chemical Property of Morpholine-4-carbohydrazide

Chemical Property:

• Refractive Index: 1.522
• PSA: 67.59000
• Density: 1.253 g/cm³
• LogP: -0.06900
• Storage Temp.: 2-8°C
• XLogP3: -1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 145.085126602
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98%min ^*data from raw suppliers

Morpholine-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)NN

Technology Process of Morpholine-4-carbohydrazide

There total 5 articles about Morpholine-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(phenyloxycarbonyl)morpholine (69630-20-2) → morpholine-4-carbohydrazide (29053-23-4)

Guidance literature:

With hydrazine hydrate; at 80 - 90 ℃; for 12h;

DOI:10.1016/S0014-827X(97)00011-6

Reference yield: 83.0%

morpholine (110-91-8,99108-56-2) + phenyl hydrazinecarboxylate (20605-43-0) → morpholine-4-carbohydrazide (29053-23-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1039/c5sc03197d

Reference yield:

4-morpholinocarbonyl chloride (15159-40-7) → morpholine-4-carbohydrazide (29053-23-4)

Guidance literature:

With hydrazine; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2005.10.108

upstream raw materials:

4-(phenyloxycarbonyl)morpholine

4-morpholinocarbonyl chloride

2,2,2-trifluoroethyl morpholine-4-carboxylate

morpholine

Downstream raw materials:

morpholine-4-carboxylic acid (5-nitro-furan-2-ylmethylene)-hydrazide

Refernces

• 1、 Bogolubsky, Andrey V.,Moroz, Yurii S.,Mykhailiuk, Pavel K.,Dmytriv, Yurii V.,Pipko, Sergey E.,Babichenko, Liudmyla N.,Konovets, Anzhelika I.,Tolmachev, Andrey. "Facile one-pot synthesis of 4-substituted semicarbazides". . p. 1063 - 1069. Retrieved 2015/02/18.
• 2、 Cerecetto, Hugo,Di Maio, Rossanna,Ibarruri, Gerardo,Seoane, Gustavo,Denicola, Ana,Peluffo, Gonzalo,Quijano, Celia,Paulino, Margot. "Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives". . p. 89 - 94. Retrieved 2007/10/03.