Technology Process of Milverine
There total 6 articles about Milverine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
[Rh(1,3-dimesitylimidazole-2-ylidene)(cod)Cl];
In
toluene;
at 125 ℃;
for 24h;
DOI:10.1002/chem.200601155
- Guidance literature:
-
With
lithium aluminium tetrahydride; aluminium trichloride;
In
tetrahydrofuran;
at -78 - 25 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / 2, triphenyl phosphite, H2 / benzene / 48 h / 80 °C / 76000 Torr
2: 95 percent / NaClO2, NaHPO4, 30percent H2O2 / H2O; acetonitrile / 10 °C
3: SOCl2 / 1 h / Heating
4: pyridine / 2 h / Heating
5: AlCl3, LiAlH4 / tetrahydrofuran / 2 h / -78 - 25 °C
With
pyridine; triphenyl phosphite; sodium chlorite; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; 2-methyl-but-2-ene; di(rhodium)tetracarbonyl dichloride; hydrogen; dihydrogen peroxide;
In
tetrahydrofuran; water; acetonitrile; benzene;