Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester

Base Information

• Chemical Name: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester
• CAS No.: 144457-43-2
• Molecular Formula: C16H16ClNO2S
• Molecular Weight: 321.828
• Hs Code.: 2934999090
• Mol file: 144457-43-2.mol

Synonyms:Methyl 2-(2-chlorophenyl)-2-(5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl)acetate;

Chemical Property of Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester

Chemical Property:

• Vapor Pressure: 2.19E-07mmHg at 25°C
• Refractive Index: 1.617
• Boiling Point: 423.7 °C at 760 mmHg
• Flash Point: 210 °C
• PSA: 57.78000
• Density: 1.317 g/cm³
• LogP: 3.61180
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno-[2,3-c]pyridin-6(7H)-yl)acetate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7h)-yl)acetate

Technology Process of Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester

There total 7 articles about Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.8%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 2-(2-(thiophen-3-yl)ethylamino)-2-(2-chlorophenyl)acetate (1427465-90-4) → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate (144457-43-2)

Guidance literature:

With hydrogenchloride; In water; at 25 - 55 ℃;

DOI:10.1080/00397911.2011.635393

Reference yield: 87.2%

4,5,6,7-tetrahydro-thieno[2,3-c]pyridine (62019-71-0) + methyl 2-bromo-2-(2-chlorophenyl)acetate (85259-19-4,622835-93-2,66504-71-0) → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate (144457-43-2)

Guidance literature:

methyl 2-bromo-2-(2-chlorophenyl)acetate; With potassium carbonate; In methanol; water; at 25 ℃; for 0.166667h;

4,5,6,7-tetrahydro-thieno[2,3-c]pyridine; In methanol; water; at 60 - 65 ℃; for 6h;

DOI:10.1080/00397911.2011.635393

Reference yield:

2-(3-thienyl)ethylamine (59311-67-0) → methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate (144457-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 0.5 h / 80 - 85 °C

1.2: 20 °C

2.1: potassium carbonate / methanol; water / 0.17 h / 25 °C

2.2: 6 h / 60 - 65 °C

With hydrogenchloride; potassium carbonate; In methanol; water;

DOI:10.1080/00397911.2011.635393

upstream raw materials:

3-(2'-iodoethyl) thiophene

2-(2-chlorophenyl)glycine methyl ester hydrochloride

4,5,6,7-tetrahydro-thieno[2,3-c]pyridine

methyl 2-bromo-2-(2-chlorophenyl)acetate

Downstream raw materials:

methyl (S)-(+)-2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate

methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride

methyl (S)-(+)-2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride

Refernces